Drug-coated balloon for severe leg artery blockage in lower legs
Part of Heart & circulation clinical trials.
This trial studies a “drug-coated balloon” procedure to improve blood flow in people with severe, long-lasting poor circulation in the lower leg arteries. It may help reduce repeat blockage after treatment for selected artery lesions below the knee.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 or older.
- You have severe, long-lasting poor blood flow in a leg that affects the foot/limb (described as Rutherford category 4 or 5) lasting more than 2 weeks.
- You can provide written consent and will be able to return for follow-up visits.
- Your pregnancy test is negative (for people who can become pregnant), and you are not breastfeeding.
- Your blockage is in specific lower-leg (below-knee) arteries and is a new or non-stent-recurrent blockage, with severe narrowing (about 70% or more).
- Your kidneys are working well enough (not on dialysis, and recent kidney function is not too low), and you do not have certain serious exclusions like recent major infection or recent major stroke/heart attack.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a special balloon that releases medication to help keep leg arteries open. It's for people with narrowed or blocked arteries in the leg, either above or below the knee.
This trial looks at whether using a scraping device (atherectomy) followed by a drug-coated balloon works better for long blockages in the thigh-to-knee artery. It may help improve blood flow symptoms and keep the artery from re-narrowing, but you must meet specific artery and health criteria.
This study compares two ways of preparing a blocked leg artery before using a drug-coated balloon to open it. It aims to see if using a special scoring balloon helps the treatment work better.
This study is testing a new drug-coated stent for blocked arteries in the thigh or behind the knee. It may help people with moderate to severe leg pain or wounds by improving blood flow without needing surgery.
This study follows people with blocked blood vessels in the thigh and behind the knee to see how well a drug-coated balloon (“Luminor”) works over 5 years. It’s designed to collect real-world results and track safety and outcomes long term.
This trial tests a special balloon coated with sirolimus (a drug that helps prevent arteries from re-closing) versus a standard balloon for opening blocked arteries below the knee in people with severe leg pain or foot wounds. The goal is to see if the drug-coated balloon works better to keep the artery open longer.
Hear when a new Peripheral Arterial Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.