Ketamine for adults with severe brain injury in the ICU
Treatments studied
Part of Brain & nervous system, Injuries & trauma clinical trials.
This trial studies whether ketamine can improve outcomes for adults with severe traumatic brain injury when they are in the ICU and need sedation. It focuses on patients who have pressure monitoring inside the brain soon after admission.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be an adult (18 years or older) with traumatic brain injury
- Be admitted to the ICU
- Be within 72 hours of being admitted to the first hospital
- Have a brain-pressure monitoring device in place and require sedation
- Not be pregnant or breastfeeding, and be able to consent (or have consent available)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether a low dose of ketamine can help people with severe traumatic brain injury by reducing brain pressure and improving oxygen levels. If you have a brain monitor in place and meet safety criteria, you may be able to join.
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This study tests if ketamine is a better sedative than other medicines for patients on a breathing machine in the ICU. If you are currently sedated but not with ketamine, you may be able to join.
This study tests whether adding ketamine to sedation medications helps patients recover better after they no longer need a breathing machine in the hospital. Researchers want to see if it reduces confusion and speeds up healing.
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This trial tests three common sedatives (propofol, midazolam, and dexmedetomidine) to see which works best for controlling pressure inside the skull after a traumatic brain injury. The goal is to find the safest and most effective option for patients in the intensive care unit.
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