Comparing sedatives for brain swelling after injury
Treatments studied
Part of Brain & nervous system, Injuries & trauma clinical trials.
This trial compares three common sedative medications used to control pressure inside the skull after a traumatic brain injury. The goal is to see which medication works best and is safest for recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old.
- You must have a moderate or severe traumatic brain injury that needs you to be sedated in the intensive care unit.
- You must have had urgent brain surgery or a pressure-monitoring device placed within 24 hours after the injury.
- Your blood pressure must be stable, either on its own or with only a low dose of medication to keep it up.
- You must not have severe liver or kidney disease, or a known allergy to propofol, midazolam, or dexmedetomidine.
- You must not be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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