Clin2
NCT07639359Possibly a fitRecruiting

Ketamine for depression in intensive care patients

Critical IllnessDepressive Symptoms

Treatments studied

Part of Mental health clinical trials.

This study tests whether low-dose ketamine infusions can reduce depressive symptoms in patients staying in the intensive care unit for at least 6 days. Ketamine is a medication that may work differently than standard antidepressants and could provide faster relief.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
50 people
Ages
18 years to 99 years
Study type
Interventional

Who can take part

  • You are 18–99 years old and have been in the ICU for 6 or more days
  • You have moderate to severe depression symptoms (PHQ-9 score of 10 or higher)
  • You can understand and agree to participate in the study
  • You are medically stable (normal oxygen, blood pressure, heart rate, and breathing rate)
  • You weigh between 45 kg and 115 kg (roughly 99–253 pounds)
  • You do not have a history of psychosis, hallucinations, dementia, or certain psychiatric conditions

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07768618Not yet recruiting· Phase 2
How a single dose of ketamine affects brain activity in people with depression

This study looks at how a single low dose of ketamine (a medication that can lift mood) affects brain electrical activity in people who are already having brain electrodes placed for epilepsy monitoring. If you have mild depression symptoms, you might benefit from this research.

Atlanta, Georgia
NCT06767358Not yet recruiting· Phase 3
Ketamine for sedation in the intensive care unit

This study tests whether ketamine, a sedative and painkiller, works better than usual sedatives in ICU patients who need help breathing. If you qualify, taking part may help reduce the amount of other sedatives you need.

Hamilton, Ontario
NCT06085937Recruiting· Phase 1
Ketamine for suicidal patients in the ER

This trial tests if a single dose of ketamine can quickly reduce suicidal thoughts in people who come to the emergency department. If you are having active suicidal thoughts and need inpatient care, you may be able to join.

Kansas City, Kansas
NCT07139106Not yet recruiting· Phase 4
Ketamine for suicidal thoughts in depression

This study tests whether ketamine can help reduce suicidal thoughts in people with depression. It also looks at how ketamine affects a brain receptor that may be linked to mood and stress, to learn why it might help.

New York, New York
NCT06668571Recruiting· Phase 2
Ketamine for treatment-resistant depression

This study tests if intravenous ketamine can help people with treatment-resistant depression who haven't found relief from at least two other treatments. If you qualify, you'll receive ketamine infusions to see if it improves your mood.

Rochester, Minnesota
NCT06891300Recruiting· Phase 2/Phase 3
Ketamine for Suicidal Thoughts in Depression

This study tests if ketamine can help reduce suicidal thoughts in people with major depression. You'll receive ketamine treatment and be monitored closely.

Ottawa, Ontario

Hear when a new Critical Illness trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.