Pre-surgery radiation plus an anti-cancer drug for soft tissue sarcoma
Treatments studied
Part of Cancer clinical trials.
This Phase 2 trial tests whether giving radiation before surgery, along with anlotinib and penpulimab, can improve treatment for localized soft tissue sarcoma. It may help shrink or control the tumor before conservative surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 years or older
- You have a confirmed diagnosis of soft tissue sarcoma (in the arm/leg or trunk) that can be treated before surgery
- The tumor can be measured/assessed on scans
- You can safely receive radiotherapy and anlotinib (and have your suitability reviewed by the study team)
- You agree to use effective contraception during the study
- You understand the study and sign informed consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a shorter course of radiation before surgery is effective for soft tissue sarcomas in certain locations. It aims to make treatment more convenient while maintaining good results.
This trial tests a new approach for high-risk soft tissue sarcoma of the arm, leg, or trunk. Before surgery, you would receive chemotherapy combined with local hyperthermia (a treatment that gently heats the tumor area) to see if this can improve outcomes.
This trial studies whether adding a chemotherapy medicine called trabectedin to targeted radiation can help control certain soft tissue sarcomas. It focuses on specific cancer types and locations, aiming to shrink tumors while keeping radiation safe for nearby healthy organs.
This trial tests whether adding immunotherapy drugs (anlotinib and penpulimab) to radiation before surgery can help treat soft tissue sarcoma—a type of cancer in muscles, fat, or connective tissue. The goal is to shrink the tumor and improve surgical outcomes.
This trial tests if giving a short course of radiation therapy combined with immunotherapy before surgery can improve outcomes for people with soft tissue sarcoma in the belly or pelvis. It is for patients whose tumors are hard to remove completely without this pre-treatment.
This trial tests combining anlotinib (a targeted therapy), doxorubicin (chemotherapy), and radiation given before surgery to shrink high-grade soft tissue sarcomas. The goal is to make the tumor easier to remove and improve outcomes.
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