Heating therapy before surgery for high-risk soft tissue sarcoma
Treatments studied
Part of Cancer, Injuries & trauma clinical trials.
This trial tests a new approach for high-risk soft tissue sarcoma of the arm, leg, or trunk. Before surgery, you would receive chemotherapy combined with local hyperthermia (a treatment that gently heats the tumor area) to see if this can improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed high-risk soft tissue sarcoma in an arm, leg, or trunk that can be removed by surgery.
- Your tumor is measurable on scans and you are healthy enough for chemotherapy and hyperthermia.
- You have not had chemotherapy or radiation for this tumor before, and you do not have cancer that has spread to other parts of the body.
- You have adequate bone marrow, liver, kidney, heart, and blood clotting function.
- You do not have metal implants in the tumor area or a heart device like a pacemaker.
- You do not have active, uncontrolled infections or certain heart conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a shorter course of radiation before surgery is effective for soft tissue sarcomas in certain locations. It aims to make treatment more convenient while maintaining good results.
This Phase 2 trial tests whether giving radiation before surgery, along with anlotinib and penpulimab, can improve treatment for localized soft tissue sarcoma. It may help shrink or control the tumor before conservative surgery.
This Phase 3 trial tests whether giving chemotherapy around the time of surgery (before/after) can improve outcomes for people with high-risk localized soft-tissue sarcoma. It uses special tumor testing (CINSARC) to help identify higher-risk patients who may benefit.
This study collects blood and tissue samples from people with high-risk soft tissue sarcoma before their surgery. The goal is to learn how the immune system responds to pre-surgery treatments like radiation and hyperthermia (heat therapy).
This trial tests whether adding a drug called L-TC (liposomal transcrocetin) to standard radiation therapy before surgery can help treat soft tissue sarcoma of the arm or leg. It is for people whose cancer is grade 2 or 3 (moderate to high grade) and has not spread to other parts of the body.
This trial tests giving chemotherapy and radiation therapy together before surgery for soft tissue sarcoma in the arms or legs. The goal is to see if this approach can improve outcomes for people with larger, high-grade, or deep tumors.
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