Deferoxamine for leptomeningeal cancer spread in the brain lining
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This Phase 1 study tests deferoxamine, a medicine given directly into spinal fluid, for leptomeningeal metastasis (cancer spreading to the brain and spinal cord lining). It’s meant to see whether the treatment can be safely given and whether it may help control this difficult-to-treat cancer location.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 or older when you sign consent
- You must be well enough to participate (either good performance score or adequate strength) and have an expected survival of at least 8 weeks
- You have leptomeningeal metastasis from a solid tumor, either newly diagnosed, returning after prior treatment, or not fully controlled after radiation or systemic therapy
- You can get an MRI with contrast dye (gadolinium) and must have normal spinal-fluid flow (no blockage hydrocephalus and no certain shunts)
- You can safely have an Ommaya reservoir placed (a device for giving medicine into spinal fluid) before the first dose
- Your blood counts and organ function must be within study limits (or your doctor can approve exceptions), and you must not be pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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