Pemetrexed in spinal fluid for lung cancer that spread to brain lining
Treatments studied
Part of Brain & nervous system, Cancer, Lungs & breathing clinical trials.
This trial tests a drug called pemetrexed, given directly into the fluid around the spinal cord (intrathecal), for people with lung cancer that has spread to the brain and spinal cord lining and is no longer controlled by the targeted therapy osimertinib.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You have non-small cell lung cancer (NSCLC) with a specific EGFR mutation (L858R or Exon19Del).
- Your cancer has spread to the membranes covering your brain and spinal cord (leptomeningeal metastasis).
- Your cancer got worse after taking a higher dose of a targeted therapy like osimertinib (Tagrisso).
- Your blood counts, liver, and kidney function must be within normal ranges.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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