Before-surgery chemotherapy vs immediate surgery for colon cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial compares giving chemotherapy before surgery versus going straight to surgery for certain stage II/III colon cancers. It may help shrink the tumor and improve outcomes by testing which approach works best for high-risk cases.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your colon cancer is confirmed by a pathology test (adenocarcinoma) or a high-grade pre-cancer change.
- Your scan shows an invasive colon cancer high in the colon (at least 12 cm from the anus).
- Your tumor markers match “pMMR” or “MSI-H” (not dMMR and not MSI-L/MSI-S).
- Your CT scan shows higher-risk local growth (high-risk T3 or T4).
- You can have major treatment safely: good blood counts, kidney and liver labs in a safe range, and energy level score 0 or 1.
- If you had a blockage, it must be relieved by a temporary stoma and you must have recovered enough to proceed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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