Tadalafil versus placebo for Fontan circulation problems
Treatments studied
Part of Heart & circulation clinical trials.
This study tests whether tadalafil (a daily pill) can improve blood flow and protect organs in adults who have had Fontan surgery. Participants will either receive tadalafil or a placebo, and they will be monitored during a planned heart catheter procedure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have had Fontan surgery (Fontan palliation) already.
- You are scheduled for a clinically needed cardiac catheterization.
- You can exercise on a bike while lying down (supine bike).
- You can and will sign written consent for the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether tadalafil can improve outcomes for people with severe pulmonary hypertension caused by COPD (chronic lung disease). It compares how you do with tadalafil versus standard care, focusing on breathing symptoms and how well your heart and lungs cope.
This trial tests whether udenafil helps teens and young people with Fontan circulation do better on exercise and breathing-related measures over time. You’d need to be on blood-thinning medicine, and be able to complete exercise testing safely.
This trial studies how the drugs sildenafil and pravastatin work in people with a single ventricle heart condition who have had the Fontan surgery and may have related liver problems. The goal is to find the best doses based on liver function.
This study checks whether special heart tests can better understand “in-between” blocked heart arteries before and after TAVI (a valve replacement done through a catheter). It may help doctors choose the safest, most accurate treatment when coronary artery disease is unclear.
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