Improving drug dosing for single ventricle patients with liver disease
Treatments studied
Part of Digestive system, Heart & circulation, Kidney & urinary clinical trials.
This trial studies how the drugs sildenafil and pravastatin work in people with a single ventricle heart condition who have had the Fontan surgery and may have related liver problems. The goal is to find the best doses based on liver function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are older than 8 years.
- You have had the Fontan procedure for your heart condition.
- You can fast (no food or drink except water) for about 8 hours before tests.
- You are willing and able to give your permission or consent to join.
- You do not have metal in your body (like certain implants) that would make an MRI unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a medication called dapagliflozin (a pill for heart failure) can help people with a Fontan circulation who feel short of breath. It aims to improve symptoms and quality of life.
This early study tests whether “liver fat” changes how a statin (rosuvastatin) works in children and teens. It may help doctors choose safer or more effective dosing in kids based on biology and a specific genetics marker.
This trial tests whether sildenafil (the drug in Viagra) can help reduce blood vessel changes in people with a left ventricular assist device (LVAD). It aims to improve heart-pump function and overall health.
This trial tests whether udenafil helps teens and young people with Fontan circulation do better on exercise and breathing-related measures over time. You’d need to be on blood-thinning medicine, and be able to complete exercise testing safely.
This trial tests if taking sildenafil before liver surgery helps patients. It is for people having a partial liver removal who are in fairly good health.
This study tests a simple liver function test (called dual cholate clearance) to see how well it works in adults with a Fontan circulation or right heart failure. It aims to help doctors better detect liver problems in these heart conditions.
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