Clin2
NCT05263674Possibly a fitRecruiting

Faster ICU treatment for non-convulsive seizures in adults

Non-Convulsive Status Epilepticus

Part of Brain & nervous system clinical trials.

This study compares two ways to stop non-convulsive seizures in the ICU. It tests whether fast sedation in intensive care works better than giving higher-dose anti-seizure medicine through a vein.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
140 people
Ages
18 years to 120 years
Study type
Interventional

Who can take part

  • You must be 18 or older.
  • Your non-convulsive seizures must be confirmed by an EEG brain-wave test.
  • You must not have responded to benzodiazepines and at least one second-line anti-seizure medicine given through a vein (levetiracetam, fosphenytoin, or valproate).
  • There should not be a brain infection causing the seizure (like meningitis or encephalitis).
  • You should not have bleeding in the brain (from injury or spontaneous bleeding).
  • You should not currently need urgent breathing tube placement (intubation) for an immediate medical reason.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04170491Recruiting
EEG monitoring for ongoing seizures in ICU

This trial studies whether using EEG (a brain-wave test) in the ICU can help guide care for people whose seizures keep going despite initial medicines. It may benefit patients with severe, difficult-to-stop status epilepticus by improving how doctors find and treat ongoing seizure activity.

London
NCT07177235Not yet recruiting· Phase 4
Ketamine for seizures that won't stop

This study tests whether ketamine can help stop seizures that haven't responded to standard treatments. It's for people with a serious condition called status epilepticus, where seizures don't stop on their own.

Philadelphia, Pennsylvania
NCT06907173Recruiting· Phase 3
Ketamine for ongoing seizures in the ER

This trial tests if adding ketamine to standard care can stop seizures that continue after a first treatment. It is for people having a convulsive seizure lasting more than 5 minutes and who are still seizing in the emergency room.

Birmingham, Alabama
NCT06549426Recruiting
Treating seizure activity after cardiac arrest

This trial tests a treatment for seizure-like brain activity that can happen after a cardiac arrest. It aims to see if treating these seizures quickly can improve recovery for people who are in a coma.

Brussels
NCT07046611Recruiting· Phase 2/Phase 3
Ketamine and Levetiracetam for Seizures in Children

This study tests whether two medicines, ketamine (a sleep medicine) and levetiracetam (a seizure medicine), work better than a standard treatment for stopping long-lasting seizures in children when the first rescue medicine doesn't work.

Sohag
NCT03457831Recruiting
Check a treatment approach for prolonged seizure emergencies

This trial is for adults in the intensive care unit who are having seizures that last at least 5 minutes or keep coming back without fully recovering. It tests a study approach for managing a dangerous seizure emergency and may help doctors improve care for critically ill patients.

Angoulême

Hear when a new Non-Convulsive Status Epilepticus trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.