Treating seizure activity after cardiac arrest
Part of Brain & nervous system clinical trials.
This trial tests a treatment for seizure-like brain activity that can happen after a cardiac arrest. It aims to see if treating these seizures quickly can improve recovery for people who are in a coma.
Summary written for real people, not researchers, by Clin2.
Who can take part
- The patient is in a coma after a cardiac arrest that happened outside the hospital.
- The patient is 18 years or older.
- A continuous brain wave test (EEG) was started within 24 hours after their heart started beating again.
- The EEG shows seizure-like activity (ESE) that is either definite or possible.
- Treatment can be started within 3 hours of seeing that seizure activity on the EEG.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study looks at tests that may help predict outcomes in people who remain in a coma 3 to 7 days after surviving a cardiac arrest. It may help doctors better estimate recovery and guide care decisions.
This study is testing whether it is safe to stop sedation and temperature management early in cardiac arrest patients who have a normal-looking brain wave test (EEG). If you qualify, you would stop sedation sooner than usual, which may help you wake up faster.
This Phase 2 trial tests a medication strategy to stop “refractory status epilepticus,” a severe seizure condition that can happen after a cardiac arrest. It may help by reducing ongoing seizure activity after return of circulation in the ICU.
This trial studies whether using EEG (a brain-wave test) in the ICU can help guide care for people whose seizures keep going despite initial medicines. It may benefit patients with severe, difficult-to-stop status epilepticus by improving how doctors find and treat ongoing seizure activity.
This study tests a seizure-prevention medicine called perampanel for people whose hearts stopped beating (cardiac arrest) and are now in the ICU. The goal is to see if it helps prevent seizures that can happen after such an event.
This trial is for adults in the intensive care unit who are having seizures that last at least 5 minutes or keep coming back without fully recovering. It tests a study approach for managing a dangerous seizure emergency and may help doctors improve care for critically ill patients.
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