Medicines to prevent graft-versus-host disease after a transplant
Treatments studied
Part of Immune system & allergy clinical trials.
This trial tests a combination of medicines (post-transplant cyclophosphamide, bortezomib, and abatacept) to lower your chance of developing graft-versus-host disease (when transplanted immune cells attack your body) after a transplant. If you qualify, you’ll receive the study medicines as part of your post-transplant care and be followed closely to check safety and prevention of GvHD.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be at least 14 years old
- Be able to do usual activities fairly well (Karnofsky score at least 70%)
- Have no ongoing, worsening infections (bacterial, viral, or fungal) before starting
- Have adequate kidney and liver function (blood test cutoffs for creatinine clearance, ALT, AST, bilirubin, and alkaline phosphatase)
- Have good heart and lung function (heart pumping strength above 45% and lung gas-exchange above 50%)
- Test negative for HIV and be able to use contraception (or not become pregnant) as required by the study, plus agree to follow all study visits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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