Preventing Graft-Versus-Host Disease After Stem Cell Transplant
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a combination of three drugs (vedolizumab, cyclophosphamide, and tacrolimus) to prevent graft-versus-host disease, a common complication after a donor stem cell transplant. It is for people with certain blood cancers who are getting a reduced-intensity transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have a blood cancer like acute leukemia in remission, myelodysplastic syndrome, myeloproliferative neoplasm, or chronic myelomonocytic leukemia.
- You have a matched related or unrelated donor available.
- You are able to perform daily activities (Karnofsky score 70% or higher).
- Your heart, lung, kidney, and liver function are within safe limits.
- You have not had a prior stem cell transplant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a combination of four medicines (cyclophosphamide, abatacept, vedolizumab, and ruxolitinib) to prevent graft-versus-host disease (GVHD) after a stem cell transplant for children and young adults with certain blood cancers. The goal is to see if this approach reduces the risk of GVHD, a serious complication where donor cells attack the body.
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