Azacitidine to help prevent kidney injury after heart surgery
Treatments studied
Part of Blood & lymphatic, Kidney & urinary clinical trials.
This early-phase study tests whether azacitidine (a medication that changes how cells read genes) can lower the risk of acute kidney injury after cardiac surgery, especially in people already at risk along the chronic kidney disease (CKD) pathway. It aims to protect kidney function during the vulnerable period after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have had cardiac surgery associated with acute kidney injury (AKI), and your AKI must be stage 2 or stage 3.
- You should NOT have chronic kidney disease (CKD) already.
- Your heart pumping strength should be okay: ejection fraction (EF) must not be below 45%.
- You must not have serious liver disease (cirrhosis classified as Child B or C).
- You should not have any active acute infection or active bleeding right now.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a treatment called RenalGuard to help protect your kidneys from damage that can happen after heart surgery. It may be helpful if you have certain risk factors like diabetes or kidney disease.
This study looks at a protein in the blood that may help predict kidney damage after heart surgery. It aims to find ways to protect kidney function during and after the operation.
This study tests whether giving amino acids (protein building blocks) during heart surgery can help protect your kidneys from damage. If you are having heart surgery and are at high risk, this treatment might reduce the chance of kidney problems afterward.
This study tests an experimental treatment using special cells from donated placentas, given through an IV, to help prevent kidney damage that can occur after heart surgery. It is for patients at high risk of acute kidney injury, a sudden loss of kidney function that can happen after the stress of surgery.
This study tests whether giving the amino acid L-arginine soon after heart surgery can help prevent acute kidney injury (a sudden drop in kidney function). If you're recovering in the ICU after heart surgery, this may help protect your kidneys.
This study looks at how heart surgery affects kidney function. It may help doctors better protect the kidneys during and after surgery.
Hear when a new Acute Kidney Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.