Heated, humid air during stem cell transplant to reduce mouth injury
Part of Digestive system, Mouth & dental clinical trials.
This Phase 2 study tests whether breathing in warm, very humid air through your nose during stem cell transplant (with high-dose melphalan) can reduce painful mouth or throat injury. It may help your comfort and recovery during and after treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be at least 18 years old (or have a legal substitute who can consent for you).
- Have non-Hodgkin lymphoma, Hodgkin lymphoma, or multiple myeloma that includes high-dose melphalan plus your own stem cell transplant.
- Plan to use the study equipment and be available and willing to follow study instructions for the whole study period.
- Have a good enough overall function level (ECOG 0 to 2).
- No major nose blockage (like nasal polyps, a badly deviated septum, or nasal packing that would block airflow or be too uncomfortable).
- No current flu-like illness, and you should not use a nighttime CPAP machine for obstructive sleep apnea.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial is testing a single injection called Amimestrocel to prevent severe mouth sores in people getting a stem cell transplant. The study is for adults who are receiving high-dose conditioning with total body irradiation or melphalan, which often cause painful mouth inflammation.
This trial tests whether inhaling tiny particles from stem cells can prevent or treat painful mouth sores caused by radiation therapy for head and neck cancer. If it works, it might make radiation treatment more comfortable.
This trial tests whether using a lavender or peppermint aromatherapy inhaler can reduce distress (stress or discomfort) for adults during stem cell transplant care. It’s for people who are getting chemotherapy before the transplant and who do not have allergies to those essential oils.
This study looks at the bacteria in your nose and throat before and after a stem cell transplant to see if they are linked to lung complications. It may help doctors predict and prevent breathing issues after transplant.
This trial tests a type of light treatment (photobiomodulation) placed in the mouth to help prevent painful mouth sores (oral mucositis) in adults getting a stem cell transplant. It may help reduce mouth discomfort and complications during transplant recovery.
This study tests whether a special, standardized mouth care routine can reduce mouth sores (called oral mucositis) in children getting a stem cell transplant. The care routine is simple and may help prevent painful mouth sores, making the transplant experience easier.
Hear when a new Autologous Stem Cell Transplant trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.