Clin2
NCT05385861Possibly a fitEnrolling by invitation

ONIVYDE plus carboplatin for advanced gut neuroendocrine cancer

GEP-NET

Part of Cancer clinical trials.

This Phase 1/2 study tests ONIVYDE® (a type of irinotecan drug) combined with carboplatin in people with advanced or metastatic gastroenteropancreatic poorly differentiated neuroendocrine carcinoma. The goal is to see how well the treatment works and how safely it can be given.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
52 people
Ages
20 years to 80 years
Study type
Interventional

Who can take part

  • Your cancer must be confirmed as advanced or metastatic gastroenteropancreatic poorly differentiated neuroendocrine carcinoma on biopsy
  • You have either not had chemotherapy before, or your last chemotherapy was given more than 6 months before your cancer came back
  • There must be at least one measurable tumor spot on scans
  • You are age 20 to 80, and your general health score (ECOG) is 0 to 1
  • Your kidneys, liver, and blood counts must be within allowed limits
  • You must have a heart rhythm test (ECG) that is normal or not clinically concerning

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05048901Recruiting· Phase 1/Phase 2
Cabozantinib plus lanreotide for advanced neuroendocrine tumors

This trial studies whether cabozantinib plus lanreotide can slow or shrink gastroenteropancreatic neuroendocrine tumors that have gotten worse despite previous treatments. If you qualify, you’ll be closely monitored for tumor response and side effects.

Changhua
NCT06485739Not yet recruiting· Phase 4
Irinotecan liposomes for high-grade neuroendocrine tumors

This trial tests a chemotherapy drug called irinotecan liposomes for people with high-grade neuroendocrine tumors or neuroendocrine cancers of the digestive system. The goal is to see if this treatment can help shrink or control the tumors.

NCT07014540Not yet recruiting· Phase 4
Liposomal irinotecan for advanced neuroendocrine carcinoma

This trial tests a new form of the chemotherapy drug irinotecan (called liposomal irinotecan) in people whose advanced neuroendocrine carcinoma has stopped responding to standard first-line treatment. The goal is to see if this special formulation can help slow or shrink the cancer.

Beijing, Beijing Municipality
NCT07026123Not yet recruiting
Onivyde based therapy for advanced pancreatic cancer

This study looks at how well a chemotherapy combination (Onivyde plus 5-FU and leucovorin) works for people with advanced pancreatic cancer in China. It may help your doctor understand if this treatment is effective for you, especially if you have already tried a gemcitabine-based treatment.

Shanghai, Shanghai Municipality
NCT06688240Not yet recruiting
Observational study of ONIVYDE after gemcitabine for advanced pancreatic cancer

This study watches how safe and effective a combination of chemotherapy drugs (ONIVYDE, 5-FU, and leucovorin) is for people with pancreatic cancer that has spread. It's for patients who have already tried gemcitabine without success, and the treatment is given as part of regular care, not as a separate experimental treatment.

NCT04325425Recruiting· Phase 2
First chemotherapy for metastatic aggressive neuroendocrine cancer

This Phase 2 study tests a chemotherapy approach in people with metastatic grade 3 (high-grade) neuroendocrine cancer or a related rare mixed tumor. It may help shrink tumors and control disease when standard first treatments have not yet been given.

Caen

Hear when a new GEP-NET trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.