Balloon treatment before birth for severe diaphragmatic hernia
Part of Genetic & congenital clinical trials.
This study looks at placing a small balloon in a baby’s windpipe before birth to help severe congenital diaphragmatic hernia (CDH). The goal is to improve lung growth and birth outcomes by testing whether this timing and method can help babies with the most severe cases.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 to 50, and you are pregnant with one baby (singleton).
- You’re between about 22 weeks and 29 weeks 6 days at enrollment.
- Your baby has severe CDH on either the left or right side based on specific ultrasound/MRI measurements, including liver herniation (as defined by the study).
- Genetic testing during pregnancy shows no major chromosome problems (karyotype or microarray normal).
- A detailed fetal heart ultrasound shows no major heart structural problems, and other scans show no extra birth defects (CDH must be isolated).
- You can stay near Lucile Packard Children’s Hospital Stanford (within 30 minutes) for the procedure period, and you plan care and delivery at Stanford.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This pilot study tests a fetal procedure (placing a tiny balloon in the fetus’s airway) to improve lung growth in pregnancies affected by severe left congenital diaphragmatic hernia (CDH). You may be eligible if your baby’s condition is isolated to the left side and the testing shows very high lung underdevelopment, and if you can meet study and payment requirements.
This trial studies a fetal procedure called FETO that places a small balloon in the baby’s windpipe to help the lungs grow in severe congenital diaphragmatic hernia (CDH). It may help babies with very small lung development after birth, but you must meet specific pregnancy, genetic, and safety requirements.
This trial tests whether placing a tiny balloon in the fetus’s windpipe can help lungs develop and improve severe pulmonary (lung) blood pressure in babies with severe congenital diaphragmatic hernia (CDH). It may lower the chance of breathing and circulation problems after birth, but it requires a specialized procedure and close follow-up in Houston.
This trial tests if placing a temporary balloon in the baby's windpipe before birth can improve survival for babies with a severe form of a diaphragmatic hernia. It is for pregnant women carrying a single baby with a left-sided hernia that is more severe or a right-sided hernia, and whose liver is up in the chest.
This trial studies whether placing a small balloon in the fetus’s airway during pregnancy (a procedure called FETO) can improve lung development and outcomes for babies with severe left congenital diaphragmatic hernia. You may be considered if the condition is isolated, very severe, and you can meet specific timing and follow-up requirements.
This study tests a fetal surgery (fetoscopic tracheal balloon placement) to help lungs grow in babies with a severe hole in the diaphragm. It focuses on pregnancies where the liver is also in the chest and lung size is very small.
Hear when a new Congenital Diaphragmatic Hernia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.