Balloon treatment for severe diaphragmatic hernia in unborn babies
Part of Genetic & congenital clinical trials.
This trial tests if placing a temporary balloon in the baby's windpipe before birth can improve survival for babies with a severe form of a diaphragmatic hernia. It is for pregnant women carrying a single baby with a left-sided hernia that is more severe or a right-sided hernia, and whose liver is up in the chest.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old and pregnant with one baby.
- Your baby has a left-sided diaphragmatic hernia with a lung-to-head ratio (a measure of lung size) below 30%, or a right-sided hernia with lung-to-head ratio at or below 45%.
- Your baby's liver is up in the chest.
- You are at less than 30 weeks pregnant at time of enrollment.
- You can stay near the hospital in Philadelphia for the rest of your pregnancy and have a support person with you.
- Your baby has no other major birth defects or genetic abnormalities.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial studies whether placing a small balloon in the fetus’s airway during pregnancy (a procedure called FETO) can improve lung development and outcomes for babies with severe left congenital diaphragmatic hernia. You may be considered if the condition is isolated, very severe, and you can meet specific timing and follow-up requirements.
This study tests a fetal surgery (fetoscopic tracheal balloon placement) to help lungs grow in babies with a severe hole in the diaphragm. It focuses on pregnancies where the liver is also in the chest and lung size is very small.
This trial tests whether placing a tiny balloon in the fetus’s windpipe can help lungs develop and improve severe pulmonary (lung) blood pressure in babies with severe congenital diaphragmatic hernia (CDH). It may lower the chance of breathing and circulation problems after birth, but it requires a specialized procedure and close follow-up in Houston.
This trial tests a special pregnancy procedure called FETO to help babies born with severe congenital diaphragm hernia (CDH) breathe better after birth. It may help by improving lung growth, but it requires close follow-up at a Chicago fetal center.
This study looks at placing a small balloon in a baby’s windpipe before birth to help severe congenital diaphragmatic hernia (CDH). The goal is to improve lung growth and birth outcomes by testing whether this timing and method can help babies with the most severe cases.
This trial tests a procedure called FETO (fetoscopic endoluminal tracheal occlusion) performed during pregnancy to help babies with congenital diaphragmatic hernia—a birth defect where part of the diaphragm (breathing muscle) has a hole and organs from the belly move into the chest. The procedure temporarily blocks the baby's windpipe to help the lungs grow bigger before birth.
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