Low-dose colchicine plus ticagrelor to prevent repeat stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation, Pain clinical trials.
This Phase 3 study tests whether low-dose colchicine added to ticagrelor (a blood-thinning medicine) helps prevent another ischemic stroke in people whose first stroke was caused by clogged arteries. It aims to lower the risk of repeat stroke after recovery from a recent event.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old
- You recently had a stroke or TIA: symptoms lasted over 10 minutes or a brain scan confirms an ischemic stroke, and you’re past the initial stabilization period
- Your stroke is from artery plaque or narrowing (atherosclerosis), shown by scan reports (carotid, brain arteries, or aortic arch plaque/thrombus)
- You are able to take long-term antiplatelet therapy (and do NOT have a clear need for long-term blood-thinners like warfarin/DOACs for heart rhythm)
- Your disability level is mild to moderate (Rankin score 0–4)
- You are not required to take colchicine for gout/“Mediterranean fever,” and you do not have major digestive inflammation
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether the anti-inflammatory drug colchicine can help prevent a second stroke in people who recently had a mild to moderate ischemic stroke. If you had a stroke 1 to 4 weeks ago and are between 18 and 80 years old, you may be able to join.
This trial tests if a drug called colchicine can reduce the risk of future strokes and improve recovery after a recent brain bleed (intracerebral hemorrhage). It is for people who also have heart or blood vessel disease or multiple risk factors like high blood pressure or diabetes.
This Phase 2 trial tests whether colchicine can help people with significant narrowing in brain arteries (from atherosclerosis) after a recent stroke or “mini-stroke.” It aims to reduce the risk related to this condition during the early period after symptoms begin.
This trial is testing whether a combination of two medicines—colchicine (an anti-inflammatory) and a low dose of rivaroxaban (a blood thinner)—can help prevent future heart attacks, strokes, or other blood vessel problems in people who recently had a stroke caused by a blood clot.
This trial tests whether adding aspirin to either ticagrelor or clopidogrel (two antiplatelet medicines) can help prevent another stroke in people who recently had a minor stroke or TIA affecting a large brain artery. It is for people who started antiplatelet treatment within 24 hours of their symptoms.
This trial tests whether adding ticagrelor or cilostazol to aspirin is better than aspirin alone for preventing another stroke. It is for patients who recently had a minor stroke or a transient ischemic attack (TIA) caused by a blockage in a large artery.
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