Low-dose colchicine plus ticagrelor to prevent repeat stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation, Pain clinical trials.
This Phase 3 study tests whether low-dose colchicine added to ticagrelor (a blood-thinning medicine) helps prevent another ischemic stroke in people whose first stroke was caused by clogged arteries. It aims to lower the risk of repeat stroke after recovery from a recent event.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old
- You recently had a stroke or TIA: symptoms lasted over 10 minutes or a brain scan confirms an ischemic stroke, and you’re past the initial stabilization period
- Your stroke is from artery plaque or narrowing (atherosclerosis), shown by scan reports (carotid, brain arteries, or aortic arch plaque/thrombus)
- You are able to take long-term antiplatelet therapy (and do NOT have a clear need for long-term blood-thinners like warfarin/DOACs for heart rhythm)
- Your disability level is mild to moderate (Rankin score 0–4)
- You are not required to take colchicine for gout/“Mediterranean fever,” and you do not have major digestive inflammation
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether taking colchicine (a medicine used for gout and inflammation) after a recent mild or moderate stroke can help prevent another stroke. If it works, it could offer a new way to reduce stroke risk.
This study tests whether colchicine, a medicine that reduces inflammation, can help people recover better and prevent future heart or brain problems after a brain bleed. It may be an option for those with certain health conditions or risk factors.
This study tests whether the drug cilostazol can help prevent another stroke or mini-stroke (TIA) in people who have already had one. It compares adding cilostazol to the standard blood-thinning medicines you and your doctor would normally use.
This study is looking at how well the blood thinner ticagrelor works to prevent new strokes and what side effects it may cause in real-life settings. If you are already taking ticagrelor for stroke, joining this study may help researchers learn more about its benefits and risks.
This Phase 2 trial tests whether colchicine can help people with significant narrowing in brain arteries (from atherosclerosis) after a recent stroke or “mini-stroke.” It aims to reduce the risk related to this condition during the early period after symptoms begin.
This trial tests whether adding aspirin to either ticagrelor or clopidogrel (two antiplatelet medicines) can help prevent another stroke in people who recently had a minor stroke or TIA affecting a large brain artery. It is for people who started antiplatelet treatment within 24 hours of their symptoms.
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