Colchicine after brain bleed to reduce disability and further strokes
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This study tests whether colchicine, a medicine that reduces inflammation, can help people recover better and prevent future heart or brain problems after a brain bleed. It may be an option for those with certain health conditions or risk factors.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had a brain bleed (intracerebral hemorrhage) within the last 72 hours.
- You have a history of heart, leg, or neck artery disease, or you have narrowing or plaque in your neck or brain arteries, or you have at least two risk factors like age 60+, high blood pressure, high cholesterol, diabetes, kidney disease, prior stroke, or smoking.
- Your brain bleed is not due to trauma, a tumor, or a bleeding disorder.
- Your brain bleed is not very large (less than 60 ml on the last scan).
- You are not in a coma or on a breathing tube at the time of consent.
- You do not have inflammatory bowel disease, chronic diarrhea, severe liver disease, or severe kidney failure.
- You are not taking certain medications that interact with colchicine, and you are not allergic to colchicine.
- You are not pregnant or breastfeeding, and you are expected to live at least 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether taking colchicine (a medicine used for gout and inflammation) after a recent mild or moderate stroke can help prevent another stroke. If it works, it could offer a new way to reduce stroke risk.
This Phase 3 study tests whether low-dose colchicine added to ticagrelor (a blood-thinning medicine) helps prevent another ischemic stroke in people whose first stroke was caused by clogged arteries. It aims to lower the risk of repeat stroke after recovery from a recent event.
This trial tests whether a low dose of the anti-inflammatory drug colchicine can help people who have recently had a heart attack or unstable angina. It aims to see if colchicine reduces the risk of future heart problems.
This study tests whether a low-dose medicine called colchicine can reduce inflammation and slow down artery blockages in people who have a specific gene change (TET2) and have recently had a heart attack. The goal is to see if it helps prevent future heart problems.
This Phase 2 trial tests whether colchicine can help people with significant narrowing in brain arteries (from atherosclerosis) after a recent stroke or “mini-stroke.” It aims to reduce the risk related to this condition during the early period after symptoms begin.
This trial tests if colchicine can reduce the risk of another stroke caused by bleeding in the brain due to a condition called cerebral amyloid angiopathy (CAA). You may qualify if you've recently had a brain bleed from CAA and have certain signs on brain scans.
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