LSD treatment for reducing the burden of cluster headaches
Part of Brain & nervous system clinical trials.
This Phase 2 trial tests LSD to see if it can reduce how much cluster headaches disrupt your life. You may be eligible if your cluster headaches are frequent and steady, and if you meet key safety and mental-health requirements.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have cluster headache, diagnosed in a specific standard way (ICHD-3)
- In the last 4 weeks, your headaches happen at least 8 times per week and don’t vary too wildly
- Before starting, your average is still at least 8 attacks per week with no long stretches (more than 2 days) without attacks
- You haven’t used LSD (or similar), psilocybin, ketamine, or cannabis in the last 3 months
- You haven’t had certain headache-related treatments recently (like steroids or nerve blocks within set time windows), and you can’t use excluded medicines during the blinded study
- You don’t have certain mental-health or brain-safety risks (like bipolar/psychosis history, high psychosis-risk screening score, alcohol/drug abuse, or a positive drug test), and if you can get pregnant you must use reliable birth control
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is testing a new device that uses mild electrical stimulation near the back of the head to prevent cluster headaches. It is for people with chronic cluster headaches that are hard to treat with standard medicines.
This trial tests a low-salt version of a medication called sodium oxybate to see if it can reduce cluster headache attacks that happen at night. It may be an option for people whose attacks are not controlled by other treatments.
This Phase 3 trial tests whether repeated injections can reduce attacks of chronic cluster headache. It may help people who have frequent, consistent attacks and can track them closely during the study.
This Phase 2 study tests whether a supervised dose of LSD (or a placebo) can reduce cluster headache attacks. It’s for people whose cluster headaches respond to oxygen, and who can safely pause certain medications and substances around the dosing day.
This study tests whether daily light therapy can reduce the number of cluster headache attacks in people with chronic cluster headache. It is a non-drug treatment that uses a special lamp to see if it helps calm your headache cycles.
This Phase 2 study tests how LSD may affect comfort and quality of life for people with advanced or end-stage life-limiting illness. It also checks whether the medicine is safe and can be given in a controlled way in palliative care settings.
Hear when a new Chronic Cluster Headache trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.