Kidney transplant with donor-matched stem cell treatment
Treatments studied
Part of Genetic & congenital, Hormones & metabolism, Immune system & allergy, Kidney & urinary, Skin, Women’s health & pregnancy clinical trials.
This early-phase trial tests a stem cell transplant from a donor who is an extremely close match, given to people who are about to receive a kidney transplant from the same donor. The goal is to improve how well the new kidney works by resetting the immune system to better accept the transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be expected to need a kidney transplant because of a specific kidney-immune/genetic condition, or because a prior kidney transplant was rejected
- You have chronic kidney disease at least stage 3
- You are taking low-dose steroids (less than 0.5 mg per kg per day)
- The kidney donor and recipient must be an almost identical genetic match for key immune genes (HLA-A, HLA-B, HLA-Cw, HLA-DQB1, HLA-DRB1)
- Your overall ability to function is enough (Karnofsky/Lansky score must be over 50)
- You must be able to give consent (or have a legal representative), and if you could become pregnant you must use effective birth control during treatment
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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