Tirzepatide vs insulin for diabetes and brain effects
Treatments studied
Part of Hormones & metabolism clinical trials.
This study tests how tirzepatide and insulin glargine affect blood sugar, fat metabolism, and brain function in adults with type 2 diabetes. It may help researchers learn which treatment changes diabetes-related body and brain processes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have type 2 diabetes (not type 1 diabetes).
- You’ve been on stable metformin (with or without sulfonylureas) for at least 2 months and doses haven’t changed.
- You are not using insulin right now (except pregnancy-related or short-term insulin for up to 14 days).
- Your A1c blood test at the start is between 7.5% and 11.0%, and your BMI is at least 23.
- You do not have certain eye, pancreas, stomach-emptying, heart, liver, or kidney problems listed in the study. (Examples: pancreatitis history, major diabetic eye disease, gastroparesis, recent heart failure/heart attack/stroke, serious kidney disease).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares an AI-powered lifestyle coaching program with a medication called tirzepatide for people who are overweight or obese and have recently been diagnosed with type 2 diabetes. The goal is to see which approach is more effective in managing weight and blood sugar.
This trial tests whether tirzepatide, a medication that helps control blood sugar and weight, can safely improve how your body handles sugar when you have type 1 diabetes. The study looks at short-term effects and may help people who are overweight and use an insulin pump or automated system.
This study looks at how well the medicine tirzepatide works in real life for adults who are overweight (BMI 30 or more) and have prediabetes or type 2 diabetes. It aims to see if the medicine helps control blood sugar and weight, and it's important that you have had a recent eye exam before starting.
This study tests a medication called tirzepatide for people with type 1 diabetes who also have overweight or obesity. Tirzepatide may help with weight loss and blood sugar control, and you'll use a continuous glucose monitor throughout the study.
This trial studies tirzepatide to see if it can slow the progression of coronary artery plaque in people with type 2 diabetes. It uses special heart CT scans to track changes over time.
This study tests a weekly injection called tirzepatide in people with type 1 diabetes who are overweight or have obesity. The goal is to see if it helps with blood sugar control and weight loss when added to insulin therapy.
Hear when a new Type 2 Diabetes Mellitus trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.