Treatment
Tirzepatide clinical trials
We’re tracking 81 recruiting studies that include Tirzepatide, each written for real people, not researchers, below.
Recruiting studies
- NCT07191873RecruitingPhase 4
Tirzepatide for treating high pressure in the brain
This trial tests if tirzepatide can help lower the pressure inside your skull caused by a condition called Idiopathic Intracranial Hypertension. It's designed for people with a BMI of 30 or higher who have swelling of the optic nerve.
Durham, North CarolinaAges 18–60 - NCT07423247RecruitingPhase 4
Tirzepatide for weight loss in kidney transplant patients
This trial tests if tirzepatide can help people who have had a kidney transplant and are still overweight lose weight. It may be an option if you have had your transplant at least a year ago, your kidney function is stable, and your body mass index is 27 or higher.
TehranAges 18 years+ - NCT07574723Recruiting
Tirzepatide dosing strategy to manage side effects in obesity
This study tests a new medication called tirzepatide, given at carefully adjusted doses, to help people with obesity lose weight while reducing unwanted side effects. Tirzepatide is a newer injectable medicine that helps control appetite and blood sugar.
Kuwait CityAges 18–100 - NCT06937086RecruitingPhase 3
Mirikizumab plus tirzepatide for UC with obesity
This study tests whether adding mirikizumab to the weight-loss drug tirzepatide helps people with moderate-to-severe ulcerative colitis who also have obesity or overweight. It aims to see if the combination reduces bowel inflammation and helps with weight management.
Dothan, AlabamaAges 18–70 - NCT07693608Enrolling by invitationPhase 2
Tirzepatide for weight loss in stimulant use disorder
This trial tests whether a weekly injection called tirzepatide (a diabetes and weight-loss medication) can help people with obesity and stimulant use disorder reduce stimulant use and lose weight. It aims to see if treating both conditions together improves outcomes.
Dallas, TexasAges 18–65 - NCT06937099RecruitingPhase 3
Testing two drugs for Crohn's with weight issues
This trial tests two study drugs, mirikizumab and tirzepatide, in people with moderate to severe Crohn's disease who also have overweight or obesity. The goal is to see if these treatments can help control Crohn's symptoms and inflammation.
Dothan, AlabamaAges 18–70 - NCT07218445RecruitingPhase 4
Tirzepatide for hot flashes in postmenopausal women with obesity
This study tests whether tirzepatide, a weekly injection, can reduce hot flashes and slow biological aging in postmenopausal women with obesity. It may help if you are experiencing bothersome hot flashes and are willing to follow a diet and exercise plan.
Jacksonville, FloridaAges 46–60 - NCT07046819RecruitingPhase 2
Tirzepatide for liver disease linked to alcohol use
This trial tests if tirzepatide, a medication that helps with weight and blood sugar, can improve liver health in people with alcohol use disorder who also have fatty liver disease. It aims to reduce liver fat and related risks.
Bethesda, MarylandAges 21–100 - NCT06651177RecruitingPhase 2
Tirzepatide with buprenorphine for opioid use disorder
This study tests whether adding tirzepatide, a medication used for weight and blood sugar, to buprenorphine treatment helps people with opioid use disorder. It aims to see if the combination improves outcomes compared to buprenorphine alone.
Jacksonville, FloridaAges 18 years+ - NCT06820281RecruitingPhase 2
Tirzepatide for type 1 diabetes: a metabolism study
This study tests if tirzepatide, a medicine that helps lower blood sugar and manage weight, is safe and effective for people with type 1 diabetes who are overweight or have obesity. You must already use an automated insulin pump system.
Sydney, New South WalesAges 18–65 - NCT06439277RecruitingPhase 3
Tirzepatide for teens with obesity and related health problems
This study tests a medication called tirzepatide (a once-weekly injection) to help teenagers with obesity and related health conditions lose weight. It aims to see if the drug is safe and effective for this age group.
Los Angeles, CaliforniaAges 12–17 - NCT07573163RecruitingPhase 2
Tirzepatide after adrenal surgery for mild cortisol condition
This trial tests if tirzepatide can help with weight and blood pressure after you have surgery to remove an adrenal gland that's making too much cortisol. It may be a good option if you still have health issues like high blood pressure or obesity after surgery.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07091734RecruitingPhase 2
Tirzepatide for partial lipodystrophy: a new treatment study
This trial is testing a medication called tirzepatide (Mounjaro) to see if it can help people with a rare fat disorder called familial partial lipodystrophy. The study hopes to improve blood sugar control and lower triglycerides, which are often high in this condition.
Ann Arbor, MichiganAges 18 years+ - NCT07293325Recruiting
Semaglutide and Tirzepatide for slowing aging in adults with obesity
This trial tests if two newer weight-loss medications, semaglutide and tirzepatide, can help slow the aging process in adults with obesity. It compares the drugs to each other and to a placebo to see which might offer anti-aging benefits beyond weight loss.
HangzhouAges 18–75 - NCT06518837RecruitingPhase 2
Tirzepatide for weight loss in early breast cancer
This study tests if tirzepatide (a weight loss drug) can help women and men with early-stage hormone receptor-positive breast cancer who are overweight or obese. The goal is to see if losing weight can improve outcomes after completing their initial breast cancer treatment.
Elizabeth, New JerseyAges 18 years+ - NCT07559500RecruitingPhase 1
Study of tirzepatide for alcohol use disorder
This trial tests if tirzepatide, a diabetes drug, affects brain chemistry linked to alcohol use. Researchers want to see if it can help people with mild-to-moderate alcohol use disorder who also have tried stimulants.
Bethesda, MarylandAges 21–65 - NCT07257484RecruitingPhase 4
Tirzepatide study for breast cancer survivors with obesity
This trial tests if tirzepatide, a weight-loss medication, can help postmenopausal women with hormone-positive breast cancer who have obesity. It aims to improve health outcomes after completing cancer treatment.
New York, New YorkAges 18 years+ - NCT07602699RecruitingPhase 2
Tirzepatide to Help People Quit Smoking
This study tests whether tirzepatide, a medication that helps with weight and blood sugar, can also help people quit smoking. You'd receive the medication plus standard quitting support (nicotine patches or gum and a quit-smoking app) over several months.
Los Angeles, CaliforniaAges 21–65 - NCT07707778Enrolling by invitationPhase 4
Tirzepatide for Weight and Aging in People with HIV
This trial tests whether a weight-loss medicine called tirzepatide can slow biological aging and improve metabolism in people with HIV who are already on effective treatment. It may help you reduce weight and possibly reverse some signs of aging.
TaipeiAges 18 years+ - NCT05553093RecruitingPhase 4
Tirzepatide vs insulin for diabetes and brain effects
This study tests how tirzepatide and insulin glargine affect blood sugar, fat metabolism, and brain function in adults with type 2 diabetes. It may help researchers learn which treatment changes diabetes-related body and brain processes.
Nanjing, JiangsuAges 18–75 - NCT05708859RecruitingPhase 4
Tirzepatide to slow plaque buildup in coronary arteries
This trial studies tirzepatide to see if it can slow the progression of coronary artery plaque in people with type 2 diabetes. It uses special heart CT scans to track changes over time.
Torrance, CaliforniaAges 40–80 - NCT05912621RecruitingPhase 2
Tirzepatide for fat-related body dysfunction in overweight adults
This Phase 2 study tests whether tirzepatide can improve how your body handles fat (especially in people with overweight or obesity) and reduce fat-related “lipotoxicity.” It may help with body fat function and related health markers, but you must meet specific health and medication rules.
Palo Alto, CaliforniaAges 18–70 - NCT05933499RecruitingPhase 2
Tirzepatide and bimagrumab for body fat and insulin sensitivity
This Phase 2 study tests two medicines to see how they change body fat, insulin sensitivity, and bone health in adults with obesity. It may help people who have tried lifestyle changes to lose weight but have not been able to, though diabetes and several health conditions must be ruled out first.
Boston, MassachusettsAges 18 years+ - NCT06191848RecruitingPhase 4
Tirzepatide for obesity and knee osteoarthritis
This trial tests a once-weekly injection called tirzepatide to help people with obesity and severe knee osteoarthritis lose weight and potentially reduce knee pain. It may be a good option if you're already waiting for knee replacement surgery and have struggled to lose weight in the past.
Fitzroy, VictoriaAges 18 years+
What Tirzepatide is being studied for
Conditions with recruiting Tirzepatide studies.
Common questions
- Are there clinical trials studying Tirzepatide?
- Yes. Clin2 currently lists 81 recruiting studies that include Tirzepatide, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Tirzepatide trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Tirzepatide an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Tirzepatide or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.