PET scan study of heart filling and blood flow in sickle cell
Part of Blood & lymphatic, Genetic & congenital clinical trials.
This study uses a PET scan to look for links between abnormal heart “filling” problems and how well blood reaches the heart muscle in people with sickle cell disease. The results may help explain early heart changes in sickle cell and guide future care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18 to 21 years old
- Be Black
- Have sickle cell disease with HbSS or HbS beta-zero thalassemia (HbSβ0thalassemia) genotype
- Fall into one group based on your echocardiogram: diastolic dysfunction (3+ abnormal measures) or no diastolic dysfunction (2 or fewer)
- If you are a healthy control, you must not have any sickle cell genotype and must have 2 or fewer abnormal diastolic measures
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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