Mianserin plus SSRIs for depression with sleep trouble
Treatments studied
Part of Mental health clinical trials.
This study tests whether adding mianserin to an SSRI (a common antidepressant) can improve depression in people whose main problem also includes sleep trouble. It may help by targeting both mood symptoms and difficulty sleeping.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have major depression diagnosed (DSM-5) with confirmed scores showing moderate-to-severe symptoms (HAMD-17 ≥ 17 and HAMA ≥ 14).
- You have sleep problems, such as a PSQI score above 7.
- You’re Han Chinese and age 18 to 60, and you can complete study interviews and rating forms.
- You have not had manic episodes (or mild manic symptoms) in the past.
- You have not taken antidepressants or sleep/relaxing medicines in the last 2 weeks (or you can complete a 7-day washout if you did).
- You are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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