Testing how CPAP affects brain waste clearance during sleep
Part of Brain & nervous system, Lungs & breathing, Mental health clinical trials.
This study looks at how stopping CPAP for 14 nights affects “brain waste clearance,” a process your brain uses to clear byproducts during sleep. It is testing whether using CPAP versus stopping it changes this brain cleanup in adults with severe obstructive sleep apnea (OSA).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 35 to 65 years old and live in the community (not in a care facility full-time).
- You have sleep study–confirmed severe OSA (AHI 30+/hour overall and NREM AHI 15+/hour).
- You have been using CPAP consistently for at least 3 months, averaging 5+ hours per night, 5+ nights per week.
- You agree to stop using CPAP for 14 nights as part of the study.
- You can give informed consent and speak and understand English well enough for study steps.
- You are not a commercial driver and you do not have certain major health conditions that make CPAP withdrawal unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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