Test EPO and melatonin for brain bleeding in very preterm babies
Part of Blood & lymphatic, Brain & nervous system clinical trials.
This Phase 1 trial studies whether giving erythropoietin (EPO) and melatonin is safe in very preterm infants who have bleeding in the brain (intraventricular hemorrhage) or significant nearby brain injury. It aims to see if these medicines can be given safely during the early days after birth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your baby was born between 22 and 31 weeks of pregnancy (gestation)
- Your baby has brain bleeding (IVH) or moderate-to-severe white-matter injury within 21 days after birth
- For babies born before 30 weeks: enrollment can be until day of life 30; for 30–31+6 weeks: enrollment until day of life 21
- Treatment must start no later than 33 weeks and 0 days of corrected age (PMA)
- Your baby’s main neonatologist agrees and a legal caregiver can give consent
- Your baby does not have certain limits (listed below) like a breathing machine mode called jet ventilation, or major interacting drug trials
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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