Ondansetron to help prevent fainting during sleep
Treatments studied
Part of Heart & circulation clinical trials.
This Phase 3 trial tests whether ondansetron can help prevent sleep-related fainting (syncope) from happening again. You might benefit if you’ve had fainting episodes during sleep and otherwise have a structurally normal heart.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’ve had fainting episodes that meet the trial’s standard definition
- You had at least one fainting episode during sleep in the last year
- Your symptom score is high enough based on the Calgary Syncope Symptom Score for people with structurally normal hearts
- You are 18 years or older and can give informed consent
- You are able to take the study medicine and follow study requirements
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests whether ondansetron can help prevent future fainting (vasovagal syncope) in adults who have had recent episodes. If it works, it may reduce how often you faint and improve safety in everyday situations.
This Phase 3 study tests whether atomoxetine can reduce how often vasovagal fainting happens. It may help people who have frequent fainting episodes with triggers like stress or standing for long periods.
This study looks at people who have had repeated fainting spells and still don’t know the cause. It tests whether different types of heart monitoring (like tilt testing or an ECG/heart tracing) can better explain what’s triggering syncope and guide prevention.
This trial helps emergency departments use a simple risk score to guide care for adults who faint. It looks at whether using these recommended steps improves how syncope (fainting) is assessed and managed in the ER.
This study tests a new way to detect and warn about fainting in people with certain types of syncope (temporary loss of consciousness). It may help those who have already had a specific fainting evaluation called an ARS assessment.
This trial tests whether ondansetron can help people with atrial fibrillation (an abnormal heart rhythm) around the time of elective catheter ablation. It may improve the safety or effectiveness of the procedure by targeting a pathway involved in heart rhythm events.
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