Ondansetron to prevent fainting episodes from vasovagal syncope
Treatments studied
Part of Brain & nervous system clinical trials.
This Phase 2 study tests whether ondansetron can help prevent future fainting (vasovagal syncope) in adults who have had recent episodes. If it works, it may reduce how often you faint and improve safety in everyday situations.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had at least one fainting spell in the past 12 months
- Your symptoms fit the study’s vasovagal fainting pattern (scored by a clinic questionnaire)
- You are 18 years or older and can give informed consent
- You do not have other known causes of fainting like certain heart rhythm problems or blood pressure drops when standing
- You are not pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at whether using a tilt-table (a special table that tilts you upright to trigger fainting) helps doctors better understand and treat fainting caused by vasovagal syncope. If you have this type of fainting, this study could help find better ways to manage it.
This Phase 3 trial tests whether ondansetron can help prevent sleep-related fainting (syncope) from happening again. You might benefit if you’ve had fainting episodes during sleep and otherwise have a structurally normal heart.
This Phase 3 study tests whether atomoxetine can reduce how often vasovagal fainting happens. It may help people who have frequent fainting episodes with triggers like stress or standing for long periods.
This trial tests whether ondansetron can help people with atrial fibrillation (an abnormal heart rhythm) around the time of elective catheter ablation. It may improve the safety or effectiveness of the procedure by targeting a pathway involved in heart rhythm events.
This trial tests whether a nausea medicine called ondansetron helps people feel better and lets doctors work more efficiently during a camera test (endoscopy) for upper GI bleeding. If you need an emergency endoscopy for bleeding, ondansetron may reduce discomfort.
This Phase 3 trial tests whether ondansetron (a medicine used to reduce nausea and vomiting) works better than a placebo, along with usual care, for adults with acute gastroenteritis. It also checks how safe ondansetron is in this setting, especially for the heart rhythm and other side effects.
Hear when a new Syncope trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.