Switching from cigarettes to heat-not-burn to protect heart arteries
Part of Heart & circulation, Mental health clinical trials.
This study looks at whether switching from regular cigarettes to a tobacco heating product slows buildup of plaque in the heart arteries. You’d be guided through smoking change and monitored using heart scans, to see if artery plaque stays the same or improves.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re between 18 and 74 years old
- You have stable coronary artery disease, seen on a heart CT scan (at least one plaque blockage of 20% or more)
- You have smoked enough in the past (at least 10 pack-years) and currently smoke at least 10 cigarettes per day
- A urine test for nicotine (“cotinine”) must be positive, showing recent smoking
- You’ve been told to quit, but you are not ready to set a quit date within the next 30 days
- Your current heart condition and medicines are stable, and you can consent to the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests how people may misuse or become dependent on heated tobacco products (a type of electronic device that heats tobacco instead of burning it). If you qualify, you'll spend 10 days in a clinic and try these products to help researchers understand their effects.
This study looks at how people puff on a heated tobacco device (a device that warms tobacco instead of burning it). You'll use the device for a while, and researchers will measure your smoking behavior to understand how it compares to regular cigarettes.
This early study checks whether very low-nicotine cigarettes change heart-related measurements during a lab visit. It may help researchers understand how lowering nicotine could affect cardiovascular (heart and blood vessel) function.
This study tests whether having access to a heated tobacco product (a device that heats tobacco, not burns it) helps current cigarette smokers quit smoking. You'll try four different flavors over a week and then continue using one you like.
This study tests whether switching to e-cigarettes or nicotine pouches can help smokers who have tried many times to quit. If you are a heavy smoker (at least 5 cigarettes a day) and have failed to quit before, this trial may offer a new way to reduce harm from smoking.
This trial tests whether a strong quit plan using varenicline (a quit pill) plus nicotine e-cigarettes, along with counseling, helps people stop smoking after a recent heart-related event. It’s aimed at people who want to quit and can safely stay involved for about a year.
Hear when a new Coronary artery disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.