Clinical trials
Coronary artery disease clinical trials
Narrowing of the arteries that supply blood to the heart. We’re tracking 712 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06855537RecruitingPhase 4
Treating unstable plaques that are not fully blocked
This trial compares treatments for heart patients who have a dangerous, but not fully blocking, fatty plaque in their arteries. It aims to see if treating these plaques with a stent or balloon can prevent future heart problems.
Beijing, Beijing MunicipalityAges 18–80 - NCT07830719RecruitingPhase 2
Study of a new drug for heart disease and inflammation
This study tests a new medicine called YMI024 for people with stable coronary artery disease (blockages in heart arteries) and higher than normal levels of inflammation. The drug aims to reduce inflammation and may lower the risk of future heart problems.
Fairhope, AlabamaAges 18–80 - NCT04027244Recruiting
Studying care plans for severe leg blood flow problems
This study looks at how best to manage severe leg ischaemia, a condition where blood flow to the leg is dangerously reduced. It mainly involves patients who are planning an intervention, and some participants may also do special heart imaging tests.
Leicester, LeicestershireAges 18–110 - NCT04973579Recruiting
Stent plus heart surgery for high risk carotid patients
This trial looks at whether doing carotid artery stenting at the same time as heart surgery is safe and effective for people at high risk of stroke around the time of surgery. It targets people with significant carotid narrowing who also need heart surgery for specific heart problems.
KrakowAges 18 years+ - NCT01384721Recruiting
CT scan study for heart artery disease risk
This study uses a CT heart scan (with a calcium score) to better understand risk in people with suspected coronary artery disease. You may be asked to have scan-based measurements and then be followed for at least a year.
Milan, MIAges 18 years+ - NCT04220047Recruiting
Surgery changes for preventing irregular heart rhythms during bypass
This trial studies whether removing a small heart pouch area and a specific ligament during off-pump heart bypass surgery improves outcomes. It is meant for people having their first off-pump coronary bypass, without a history of atrial fibrillation.
BeijingAges 18–80 - NCT04827498Recruiting
Testing heart blood-flow problems without clogged arteries
This study looks at how well the heart’s blood vessels work in people who have symptoms of reduced blood flow but no major artery blockage. It uses special heart tests with medicines to check how the vessels respond and may help guide better diagnosis and treatment.
MadridAges 18 years+ - NCT05078814Recruiting
Survey of a heart and leg condition’s gene differences
This study collects information to understand how often certain genetic variants (ALDH gene family) show up in people with blocked leg arteries or an acute heart condition. The results may help researchers better understand the biology behind these illnesses.
TainanAges 20 years+ - NCT04185285Recruiting
Heart procedure registry for people who had stents
This trial is a registry that collects information from people who receive a heart artery procedure (percutaneous coronary intervention) at the study hospital. It mainly helps researchers understand outcomes and care patterns, and it only requires your consent to participate.
FribourgAges 17–120 - NCT05230446Recruiting
Testing full stent treatment for heart artery blockages
This study looks at how well doctors can treat multiple blocked heart arteries using a specific drug-eluting stent, aiming to fully open them. It may help patients whose blockage pattern fits the study, but it does not include certain high-risk or special cases.
Rotterdam, South HollandAges 18–85 - NCT05250557Recruiting
Study heart blood-flow measurements to predict outcomes in coronary disease
This study looks at a specific heart blood-flow measurement taken during a coronary procedure to see how well it predicts future outcomes. If you had a successful pressure measurement called FFR with a tracing, your results may be analyzed to understand risk and prognosis.
SeoulAges 20 years+ - NCT05353946Recruiting
Rotational atherectomy elective vs emergency for heavily calcified blockages
This trial compares doing a special procedure (rotational atherectomy) before an emergency is needed versus using it as a rescue during a heart artery procedure. It is designed for people with very hard, calcified artery blockages and long-term kidney impairment, to see which approach works better and is safer.
MadridAges 18–100 - NCT03479580Recruiting
Registry for coronary and small-vessel heart disease in cardiomyopathy
This study enrolls people with certain types of heart muscle diseases to learn how blocked heart arteries and tiny blood vessels affect symptoms and outcomes. It may help researchers better understand these conditions and improve future care.
La TroncheAges 18–100 - NCT05380622Recruiting
CT scan to study plaque and blood flow in heart disease
This study uses a special heart CT scan (coronary CT angiography) to look at plaque and how blood flows in people with coronary artery disease. It may help match your scan results with heart measurements and guide future care decisions.
ShanghaiAges 18 years+ - NCT05337319Recruiting
Registry for people in the hospital with coronary artery disease
This study keeps a careful record of what care people with coronary artery disease receive while they are hospitalized. It may help doctors improve future treatment by showing what is happening in real-world practice.
BeijingAges 18 years+ - NCT04011527Recruiting
Registry for heart stent procedure using rotational atherectomy
This study collects information from people who are having a heart procedure called rotational atherectomy to open blocked heart arteries. It helps doctors better understand how the procedure is used and its outcomes.
Bad SegebergAges 18–100 - NCT05509010Recruiting
AI registry using CT scan to assess coronary artery disease
This trial builds and tests an AI system using information from a heart CT scan to help evaluate coronary artery disease (clogged heart arteries). If you need a CT coronary angiography for medical reasons, this may help improve how such scans are analyzed and used in care.
SingaporeAges 21–80 - NCT05532631Recruiting
Compare stent procedure versus bypass surgery for weak heart
This study compares two ways to improve blood flow to the heart—using stents through a catheter or bypass surgery—in people with heart muscle weakness and blockages in more than one coronary artery. It may help identify which approach leads to better outcomes over at least two years.
Créteil, Val De MarneAges 18 years+ - NCT03209414Recruiting
Study of frailty in heart patients receiving heart care
This trial looks at “frailty,” meaning reduced strength and resilience, in older adults with coronary artery disease who are getting heart care. It may help doctors better understand which patients are more at risk and how care decisions could be improved.
Zabrze, Upper SilesiaAges 65 years+ - NCT04772768Recruiting
Checking problems in vein bypass grafts in people with recurring chest pain
This study looks at how vein bypass grafts are working over time in people who had heart bypass surgery and now have recurring angina (chest discomfort). It may help doctors better understand why symptoms come back and how the heart and grafts change.
AmsterdamAges 18–90 - NCT02301663Recruiting
Stress test study of heart blood-flow issues in adults
This study tests a new kind of stress test to understand how small blood-vessel heart problems relate to heart relaxation problems in people with angina (chest pain) but no blocked arteries. It may help doctors learn better ways to diagnose and guide treatment for these conditions.
Los Angeles, CaliforniaAges 18–60 - NCT06089902Recruiting
European registry for anomalous aortic origin of coronary arteries
This is a European registry for people with an anomalous origin of a coronary artery from the aorta (AAOCA). It will track how the condition is treated—whether with surgery or monitoring—to learn what works best.
Padova, PDAges Any age - NCT06104033Recruiting
Drug-coated balloon for patients with heart artery disease in multiple vessels
This trial tests whether a drug-coated balloon is a good treatment option for people who have blockages in two or more heart arteries. It aims to see if this approach can safely open blocked arteries without a permanent stent.
SeoulAges 19–100 - NCT06066450Recruiting
OSFIT Stent for Coronary Artery Blockage
This trial tests a special stent (OSFIT) in people with a blockage near the start of a coronary artery. The goal is to see if the stent works well for this specific location.
SuwonAges 19 years+
Hear when a new Coronary artery disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Coronary artery disease trials by city
Studies with a site in or near these metro areas.
Coronary artery disease trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for coronary artery disease?
- Yes. Clin2 currently lists 712 recruiting coronary artery disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a coronary artery disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a coronary artery disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.