Ropeginterferon for early myelofibrosis with low-to-mid risk
Part of Blood & lymphatic clinical trials.
This Phase 2 trial studies ropeginterferon alfa-2b (a type of interferon medicine) in adults with early, lower-risk myelofibrosis. The goal is to see if it can control the disease better or improve outcomes with an acceptable safety profile.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult (18 or the local legal adult age) with myelofibrosis that is primary or after prior PV or ET
- Your bone marrow scarring is low (reticulin grade 0–1) and your risk is low or intermediate-1 (DIPSS)
- Your liver and kidney tests meet certain limits (bilirubin, ALT/AST, blood clotting time, and kidney filtration rate)
- You must be able to use reliable contraception during the study and for 28 days after the last dose; you must not be pregnant, and you must not breast-feed
- You cannot have used interferon (IFNα) for myelofibrosis recently (unless it was for prior PV/ET and the last dose was more than 4 weeks ago)
- You must not have certain conditions like major autoimmune disease, HIV with active issues, uncontrolled hepatitis B/C, severe eye disease, major depression/seizure history, recent other cancers, or recent alcohol/drug abuse
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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