Clin2
NCT05746858Possibly a fitNot yet recruiting

Biomarker study for diffuse large B-cell lymphoma

Diffuse Large B Cell LymphomaRelapsed Non-Hodgkin Lymphoma

Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.

This study looks for biomarkers (biological signs) in blood or tissue samples from people with diffuse large B-cell lymphoma (DLBCL) to help predict how the disease behaves and how well treatment might work. Participation involves giving extra biopsy or blood samples during routine care.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
300 people
Ages
18 years and older
Study type
Observational

Who can take part

  • You must be 18 years or older.
  • You must have been diagnosed with diffuse large B-cell lymphoma (DLBCL), or with DLBCL that has come back or not responded to treatment (relapsed/refractory).
  • You must be eligible for standard first-line or later chemotherapy–immunotherapy treatments.
  • You need to have at least one tumor that can be measured on imaging (larger than 1.5 cm).
  • You must not have any other active cancer or serious medical condition that might interfere with chemotherapy.
  • You need to have a tumor tissue sample (from a biopsy) available for research, and be willing to give another sample if needed.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06693830Recruiting
Blood test guided treatment for newly diagnosed DLBCL

This trial studies whether using a blood test (ctDNA) can help guide treatment decisions for people with newly diagnosed diffuse large B-cell lymphoma. It tests standard chemotherapy regimens (R-CHOP or R-pola-CHP) and aims to improve outcomes by monitoring tumor DNA in the blood.

New York, New York
NCT07070648Recruiting
Predicting DLBCL treatment response with ctDNA and PET scans

This trial uses a blood test (ctDNA) and PET scans to predict how well standard first-line treatment works for diffuse large B-cell lymphoma (DLBCL). It aims to find out if these tests can guide better care.

Shanghai, Shanghai Municipality
NCT06736613Recruiting· Phase 2
Blood test for tumor DNA in high-risk B-cell lymphoma

This trial uses a blood test to look for tumor DNA in people with high-risk B-cell lymphoma, to help predict if the lymphoma might spread to the brain or spinal cord. It may help doctors decide on extra treatments to prevent that spread.

Basking Ridge, New Jersey
NCT07714421Not yet recruiting· Phase 1
Combination treatment for older adults with large B cell lymphoma

This trial tests a new combination of drugs for people with a type of lymphoma called diffuse large B cell lymphoma, especially if you are older or not healthy enough for standard full-dose chemotherapy. The treatment includes two immunotherapy drugs (epcoritamab and polatuzumab) plus a reduced-intensity chemotherapy regimen (mini-CHP). The goal is to see if this combination is safe and effective for people who may not tolerate stronger treatments.

Los Angeles, California
NCT07750886Recruiting
Collecting samples for lymphoma research

This study collects blood and tumor tissue samples from people newly diagnosed with aggressive non-Hodgkin lymphoma who will receive standard chemotherapy. The goal is to improve future tests for detecting minimal residual disease (tiny amounts of cancer left after treatment).

Austin, Texas
NCT06516978Not yet recruiting· Phase 2
Comparing drug combinations for untreated large b-cell lymphoma

This trial tests different combinations of targeted drugs and chemotherapy for people newly diagnosed with a type of lymphoma called DLBCL. It aims to find which combination is more effective and safer.

Hear when a new Diffuse Large B Cell Lymphoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.