Safety study of a MET-targeting pill for advanced lung cancer
Part of Cancer, Lungs & breathing clinical trials.
This Phase 1 trial tests DO-2 to see how safe it is and how the body absorbs it (pharmacokinetics) in people with advanced or metastatic lung cancer. It is for tumors that have a specific MET exon 14 “skipping” mutation and for whom standard treatments are no longer an option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- Your lung cancer is advanced/has spread and cannot be removed by surgery, and you have a confirmed MET exon 14 skipping mutation (test results must be from within the last 3 months).
- Your cancer has measurable spots that can be tracked on scans.
- You can do usual daily activities fairly well (ECOG 0–1).
- You have enough working bone marrow, liver, and kidneys based on blood tests.
- You can take pills and follow the trial’s birth-control/contraception rules.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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