Low-dose methadone for chemotherapy nerve pain
Treatments studied
Part of Cancer, Pain clinical trials.
This trial studies whether methadone can reduce painful nerve damage caused by certain chemotherapy drugs. It is for adults who have ongoing nerve pain for months after chemotherapy ended and may help by lowering neuropathic (nerve) pain.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be over 18 years old
- Have a cancer diagnosis and a life expectancy of more than 12 weeks
- Have pain from nerve damage (chemotherapy-induced peripheral neuropathy) lasting at least 3 months after chemo ended, with average pain over 3 out of 10
- Be using little or no opioid pain medicine now (opioid-naïve or less than 60 mg/day of oral morphine equivalents)
- Have had specific chemotherapy types linked to nerve damage (like platinum or taxane drugs, vinca alkaloids, bortezomib, or thalidomide)
- Be able to take pills by mouth and not be pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a gentle, non-invasive brain stimulation (over the motor cortex) can help relieve pain caused by nerve damage from chemotherapy. It is for people who have completed cancer treatment at least 3 months ago and have ongoing painful neuropathy.
This Phase 2 trial tests duloxetine to see if it safely reduces painful nerve damage caused by chemotherapy (especially taxanes) in people with solid tumors. If you have moderate-to-severe nerve pain and meet lab and heart-safety checks, this study may be an option.
This trial tests whether spinal cord stimulation can reduce pain and improve quality of life in people with long-lasting nerve pain from chemotherapy (CIPN). You must already have tried at least two nerve-pain medicines and still have significant pain, and you must have had a successful spinal cord stimulator test before joining.
This study tests a new gel (VMD-3866) applied to the skin to treat moderate nerve pain, numbness, or tingling caused by previous chemotherapy. It aims to see if the gel can safely reduce pain for people whose symptoms have been stable for at least 8 weeks.
This study tests a spinal cord stimulator—a device that sends mild electrical pulses to the spine—to see if it can reduce severe nerve pain that lasts more than 6 months after chemotherapy. It is for people who have tried other treatments like duloxetine but still have significant pain.
This study tests a diet program delivered online to help reduce nerve damage symptoms like numbness and tingling caused by chemotherapy. It is for cancer survivors who completed treatment and still have these symptoms.
Hear when a new Chemotherapy-induced Peripheral Neuropathy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.