Treatment
Duloxetine clinical trials
We’re tracking 28 recruiting studies that include Duloxetine, each written for real people, not researchers, below.
Recruiting studies
- NCT07203339Recruiting
Home brain stimulation vs. duloxetine for fibromyalgia pain
This trial compares a non-invasive, at-home brain stimulation technique (tDCS) to the medication duloxetine for treating fibromyalgia pain. It aims to see if the brain stimulation works as well as the drug.
Porto Alegre, Rio Grande do SulAges 18–75 - NCT07421427Recruiting
Preventing pain after mastectomy with added medication
This trial tests if adding amantadine or duloxetine to the standard drug pregabalin can better prevent chronic pain after a mastectomy. It may help you if you're undergoing a modified radical mastectomy for breast cancer.
CairoAges 18–65 - NCT05110144RecruitingPhase 2
Testing two doses of two nerve pain medicines for chronic cough
This Phase 2 study tests whether two doses of duloxetine and amitriptyline can reduce symptoms in people with chronic cough that hasn’t responded to usual care. You may join to see if these medicines lessen cough severity over an 8-week blinded treatment period.
Rochester, MinnesotaAges 18–75 - NCT05120934RecruitingPhase 2
Two medicine doses to reduce ILD cough
This Phase 2 study tests whether two different doses of duloxetine and amitriptyline can reduce coughing caused by interstitial lung disease (ILD). If you have had a long-lasting ILD-related cough despite stable ILD treatment, this trial may help find a better way to control your cough.
Rochester, MinnesotaAges 18–75 - NCT06232473RecruitingPhase 4
Education and duloxetine for multisystem functional somatic disorder
This trial tests whether a combination of patient education and the medication duloxetine can help people with a condition that causes multiple unexplained physical symptoms (functional somatic disorder). It aims to see if using both treatments together works better than either alone.
AarhusAges 18–60 - NCT07593313Recruiting
Treatment for pain after stroke using spinal stimulation
This trial tests a treatment called spinal cord stimulation for people who develop chronic pain after a stroke. The pain is caused by the stroke itself and doesn't respond well to regular pain medicines. The treatment uses a small device to send mild electrical signals to your spinal cord to reduce pain.
Nanchong, SichuanAges 18 years+ - NCT07431606RecruitingPhase 2
Duloxetine for Inflammatory Bowel Disease
This study tests whether duloxetine, a medication used for pain and mood, can help people with inflammatory bowel disease (IBD) who are also dealing with high stress, disability, or gut-related anxiety.
Philadelphia, PennsylvaniaAges 24 years+ - NCT06914557RecruitingPhase 2
Scrambler therapy plus duloxetine for chemo nerve pain
This study tests whether adding a non-invasive device called Scrambler Therapy to the usual nerve pain medicine (duloxetine) can better relieve chemotherapy-induced nerve pain. It is for people with cancer who still have significant nerve pain despite taking duloxetine.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06860984RecruitingPhase 3
Evaluating the Safety and Efficacy of Duloxetine in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis
This phase 3 trial tests duloxetine for preventing pancreatitis after ERCP in adults with normal baseline amylase/lipase and without certain comorbidities.
TantaAges 18–65 - NCT06866444Recruiting
Duloxetine and Fibromyalgia: How Your Body Processes the Drug
This study looks at how well duloxetine (Cymbalta) works in people with fibromyalgia. It may help doctors understand if people respond differently based on how their body breaks down the drug.
Salt Lake City, UtahAges 18 years+ - NCT06807866RecruitingPhase 4
Duloxetine for pain after hip replacement surgery
This trial tests if duloxetine, a medication that helps with nerve pain, can reduce pain after hip replacement surgery. It may help patients who are having a first-time total hip replacement.
Miami, FloridaAges 18 years+ - NCT06423716RecruitingPhase 4
Duloxetine to reduce opioid use after knee replacement
This study tests whether taking the pain medication duloxetine before and after knee replacement surgery can reduce the need for opioid painkillers. It may help patients manage pain with fewer side effects from strong narcotics.
Toronto, OntarioAges 50 years+ - NCT05851976RecruitingPhase 4
Duloxetine for short-term non-radiating low back pain
This trial tests duloxetine (a medicine used for certain pain conditions and mood) for easing low back pain that started recently and doesn’t shoot down your leg. It may help reduce pain and improve daily function after an ER visit, but you must meet several safety and medication-use criteria.
The Bronx, New YorkAges 18–64 - NCT05840562RecruitingPhase 3
Capsaicin skin patch vs duloxetine for nerve pain after chemo
This Phase 3 trial tests whether a capsaicin patch works better than duloxetine tablets to reduce painful nerve pain after chemotherapy. It aims to help people whose “gloves and socks” nerve pain has lasted after chemo.
AngersAges 18 years+ - NCT04970121RecruitingPhase 2
Duloxetine for chemotherapy nerve pain in solid tumor patients
This Phase 2 trial tests duloxetine to see if it safely reduces painful nerve damage caused by chemotherapy (especially taxanes) in people with solid tumors. If you have moderate-to-severe nerve pain and meet lab and heart-safety checks, this study may be an option.
Bengbu, AnhuiAges 18–75 - NCT07731750Recruiting
Smart pain treatment plan for chronic low back pain
This study tests a computer-based tool to help choose the best pain treatments for people with chronic low back pain. It compares different treatments to see which ones work best for each person.
Ann Arbor, MichiganAges 25 years+ - NCT07400471RecruitingEarly Phase 1
Pain relief before root canal: a medicine combination
This trial tests whether a combination of pain medicines given before a root canal can lower pain afterward. It is for people who have moderate to severe tooth pain and are healthy enough for standard treatment.
Chittagong, ChattogramAges 18 years+ - NCT07326163Enrolling by invitation
Peppermint oil aromatherapy for fibromyalgia pain relief
This study tests whether smelling peppermint oil can help reduce pain and improve daily function in people with fibromyalgia, while also looking at cost. It uses a simple, non-invasive method (aromatherapy) to see if it can be a helpful addition to your current care.
Bilecik, BilecikAges 18 years+ - NCT05786599RecruitingPhase 2/Phase 3
Low-dose methadone for chemotherapy nerve pain
This trial studies whether methadone can reduce painful nerve damage caused by certain chemotherapy drugs. It is for adults who have ongoing nerve pain for months after chemotherapy ended and may help by lowering neuropathic (nerve) pain.
Nanaimo, British ColumbiaAges 19 years+ - NCT07208357Recruiting
Pregabalin with toludesvenlafaxine for fibromyalgia pain
This study tests a combination of two medications (pregabalin and toludesvenlafaxine) to see if it is safe and effective for people with fibromyalgia whose pain has not improved with non-drug treatments and who have not yet tried standard medications for this condition.
BeijingAges 18 years+ - NCT06896994Recruiting
Study of esketamine plus pregabalin and duloxetine for shingles nerve pain
This trial tests whether adding esketamine to two standard pain medicines (pregabalin and duloxetine) can better treat nerve pain from shingles that persists for months. It's for people whose pain hasn't improved enough with pregabalin alone.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07025590Recruiting
Exercise to help lower antidepressants for heart patients
This trial tests whether adding a structured exercise program can help people with both depression/anxiety and heart disease slowly reduce their antidepressant medication. It may offer a way to lower medication use while improving heart and mental health.
Guangzhou, GuangdongAges 18–70 - NCT06614322RecruitingPhase 2
Nerve damage foot pain study
This study tests whether certain pain medicines can better relieve foot pain caused by nerve damage. It compares how people's bodies respond to pain to find the best treatment for each person.
Boston, MassachusettsAges 18–80 - NCT06245109RecruitingPhase 4
Pain medicine study for knee osteoarthritis
This study tests how well different pain medicines work for knee osteoarthritis and looks at brain patterns to understand why some people get more relief. It may help you find a treatment that works best for you.
Chicago, IllinoisAges 41 years+
What Duloxetine is being studied for
Conditions with recruiting Duloxetine studies.
Common questions
- Are there clinical trials studying Duloxetine?
- Yes. Clin2 currently lists 28 recruiting studies that include Duloxetine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Duloxetine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Duloxetine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Duloxetine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.