Clin2
NCT05794750Possibly a fitNot yet recruiting

Combination therapy before surgery for rectal cancer

Locally Advanced Rectal Cancer

Treatments studied

Part of Cancer, Digestive system clinical trials.

This trial tests a new combination of treatments for locally advanced rectal cancer. It uses radiation, chemotherapy, and a drug called AK104 before surgery, and the goal is to see if it can improve results for patients.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
50 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You must be between 18 and 75 years old.
  • You must have stage II or III rectal cancer that has not spread to other parts of the body.
  • Your cancer must be the type called adenocarcinoma.
  • You must be in good overall health (able to do daily activities) and have normal blood counts and organ function.
  • You must not have had radiation or immunotherapy before.
  • You must not have severe autoimmune diseases or other serious health conditions.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06802666Recruiting· Phase 2
Short radiation plus combo drugs for rectal cancer

This trial tests a new combination for rectal cancer that hasn't spread far: a short course of radiation followed by two drugs (AK112 and CAPOX). The goal is to shrink the tumor before surgery and possibly avoid more aggressive treatments.

Hubei
NCT05998122Not yet recruiting· Phase 2
Chemotherapy, radiation, and immunotherapy before surgery for rectal cancer

This study tests a combination of chemotherapy, radiation, and an immunotherapy drug (called anti-PD-1) before surgery for rectal cancer that has not spread. The goal is to see if this approach can shrink or eliminate the tumor, potentially improving outcomes.

Changchun, Jilin
NCT06832917Not yet recruiting· Phase 3
Short-course radiation plus immunotherapy and chemo before surgery for rectal cancer

This trial tests a new treatment sequence for locally advanced rectal cancer: a short course of radiation followed by a combination of immunotherapy (cadonilimab) and chemotherapy (mFOLFOX6) before surgery. The goal is to shrink the tumor more effectively and potentially improve outcomes.

NCT07104604Recruiting· Phase 2
New combo before surgery for low rectal cancer

This trial tests a new combination of treatments (radiation, immunotherapy, and two chemotherapy drugs) given before surgery for people with a specific type of locally advanced rectal cancer that is close to the anus. The goal is to see if this approach is safe and effective.

Shantou, Guangdong
NCT07774754Not yet recruiting· Phase 2
Combination therapy for locally advanced rectal cancer

This trial tests a combination of radiation, chemotherapy, and two immunotherapy drugs (sintilimab and suvemcitug) to see if it can improve outcomes for patients with locally advanced rectal cancer that has not spread. The goal is to shrink the tumor before surgery, potentially making it easier to remove and reducing the risk of recurrence.

Guangzhou, Guangdong
NCT06647680Recruiting· Phase 2
Chemo and immunotherapy before surgery for rectal cancer

This trial tests a combination of chemotherapy and an immunotherapy drug (a PD-1 inhibitor) given before surgery for locally advanced rectal cancer. The goal is to see if this approach can improve outcomes compared to standard treatment.

Qingdao, Shandong

Hear when a new Locally Advanced Rectal Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.