Combination therapy for locally advanced rectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of radiation, chemotherapy, and two immunotherapy drugs (sintilimab and suvemcitug) to see if it can improve outcomes for patients with locally advanced rectal cancer that has not spread. The goal is to shrink the tumor before surgery, potentially making it easier to remove and reducing the risk of recurrence.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You must have a type of rectal cancer called adenocarcinoma that has not spread to distant organs.
- Your tumor must be 'microsatellite stable' (MSS) or pMMR, which means your cancer cells have normal DNA repair.
- You should not have had prior treatment for rectal cancer, like surgery, chemo, or radiation.
- Your blood counts, liver, and kidney function need to be within certain levels.
- You should not have serious heart problems or a history of blood clots in the past year.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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