Testing brain-signal biomarkers in treatment-resistant depression
Part of Mental health clinical trials.
This trial studies signs in the brain (biomarkers) during an accelerated form of nerve stimulation to treat depression that hasn’t improved with usual antidepressants. It may help researchers learn who benefits and how to better personalize treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are currently diagnosed with major depressive disorder (MDD).
- You have not improved after trying at least two antidepressants at the right dose and for long enough during this current episode.
- Your depression medications have been stable for at least 1 month.
- You do not have conditions that make magnetic stimulation unsafe (such as epilepsy, brain lesions, prior brain surgery, metal implants, or certain heart devices).
- You have not had alcohol or substance use disorder in the last 6 months, and you are not having a current intoxication or withdrawal issue.
- If you have a seizure history in you or your close family (first-degree relatives), you may not qualify; pregnancy/breastfeeding also excludes participation.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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