Testing brain-signal biomarkers in treatment-resistant depression
Part of Mental health clinical trials.
This trial studies signs in the brain (biomarkers) during an accelerated form of nerve stimulation to treat depression that hasn’t improved with usual antidepressants. It may help researchers learn who benefits and how to better personalize treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are currently diagnosed with major depressive disorder (MDD).
- You have not improved after trying at least two antidepressants at the right dose and for long enough during this current episode.
- Your depression medications have been stable for at least 1 month.
- You do not have conditions that make magnetic stimulation unsafe (such as epilepsy, brain lesions, prior brain surgery, metal implants, or certain heart devices).
- You have not had alcohol or substance use disorder in the last 6 months, and you are not having a current intoxication or withdrawal issue.
- If you have a seizure history in you or your close family (first-degree relatives), you may not qualify; pregnancy/breastfeeding also excludes participation.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
This study tests how a specific kind of brain stimulation (repetitive transcranial magnetic stimulation) works for people with depression that has not responded to standard treatments. If you qualify, it may help doctors understand the mechanism and improve options for treatment-resistant depression.
This study is testing whether brain and heart signals can help predict who will respond to rTMS, a non-invasive treatment that uses magnetic pulses to stimulate parts of the brain. You would receive rTMS for depression and undergo MRI scans and heart monitoring to see if certain patterns predict improvement.
This study is testing whether measuring your brain's electrical activity (EEG) during MRI can help personalize a type of brain stimulation treatment called TMS (transcranial magnetic stimulation) for people with hard-to-treat depression. The goal is to find early markers that predict who will respond to this treatment, so it can be tailored to each person for better results.
This trial tests a new type of brain stimulation treatment for people with major depression that hasn't improved with standard treatments. The treatment uses magnetic pulses to target specific brain areas over about 2 weeks.
This study uses brain imaging to guide a noninvasive treatment called transcranial magnetic stimulation (TMS) for people with depression. It aims to see if tailoring the stimulation to each person's brain can improve symptoms.
Hear when a new Treatment Resistant Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.