Brain wave markers to guide personalized brain stimulation for treatment-resistant depression
Part of Mental health clinical trials.
This study is testing whether measuring your brain's electrical activity (EEG) during MRI can help personalize a type of brain stimulation treatment called TMS (transcranial magnetic stimulation) for people with hard-to-treat depression. The goal is to find early markers that predict who will respond to this treatment, so it can be tailored to each person for better results.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18 and 65 years old.
- Have a medical diagnosis of major depression, confirmed by a structured interview.
- Currently be in a moderate to severe depressive episode (score of 20 or more on a standard depression rating scale).
- Have moderate to severe treatment resistance (meaning prior treatments haven't worked well enough).
- Be able to understand English well enough to complete the study procedures and questionnaires.
- Be on a stable antidepressant dose or medication-free for at least 4 weeks before and during the study.
- Not have contraindications to MRI (like metal implants) or TMS, and no prior exposure to rTMS or ECT non-response.
- Not be at high risk for suicide (as assessed by a standard questionnaire).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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