Clin2
NCT07329153Possibly a fitNot yet recruiting

Brain stimulation for treatment-resistant depression

Treatment Resistant Depression (TRD)

Part of Mental health clinical trials.

This trial tests a new type of brain stimulation treatment for people with major depression that hasn't improved with standard treatments. The treatment uses magnetic pulses to target specific brain areas over about 2 weeks.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
247 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You must be between 18 and 65 years old.
  • You must have a current major depressive episode (unipolar, not bipolar).
  • At least two prior depression treatments (like antidepressants for 6 weeks or 12 therapy sessions) must have failed to help.
  • You must have moderate to severe depression (score above 19 on a standard scale).
  • You must not have certain other psychiatric conditions like bipolar, schizophrenia, PTSD, ADHD, or OCD.
  • You must not have any metal implants in your head, a seizure history, or be taking certain medications like anticonvulsants or lithium.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07673913Recruiting
Blood markers and brain stimulation for hard-to-treat depression

This study is testing whether a new type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with treatment-resistant depression (depression that hasn't improved with standard medicines). It also looks at certain blood markers to see if they can predict how well someone will respond to this treatment.

Ankara, Ankara
NCT07758010Recruiting
Brain stimulation for treatment-resistant depression

This study tests a type of brain stimulation called cTBS (continuous theta burst stimulation) applied to a specific part of the brain (the precuneus) to see if it helps with treatment-resistant depression. It aims to provide a new option for people who haven't found relief from standard treatments.

Belmont, Massachusetts
NCT07603804Recruiting
Accelerated Brain Stimulation for Treatment-Resistant Depression

This study tests an accelerated form of iTBS (a non-invasive brain stimulation technique) for depression that hasn't improved with antidepressant medications. The goal is to help people with major depression who haven't responded adequately to at least one antidepressant drug.

Istanbul
NCT07512284Recruiting· Phase 2
Mindfulness and Brain Stimulation for Treatment-Resistant Depression

This study combines mindfulness practice with transcranial magnetic stimulation (TMS)—a non-invasive brain stimulation technique—to help people with depression that hasn't improved with antidepressant medications. The goal is to see if adding mindfulness to TMS improves how well the treatment works.

San Diego, California
NCT07529574Not yet recruiting
Brain stimulation for treatment-resistant depression

This study tests a new type of magnetic brain stimulation (called theta burst stimulation) for people whose depression hasn't improved with standard treatments. It aims to see if this treatment is safe and effective for both adults and teenagers with moderate to severe depression.

Seoul
NCT07207239Enrolling by invitation
Brain stimulation for treatment-resistant depression

This trial is testing a type of brain stimulation therapy called theta-burst rTMS to see if it helps with depression that hasn't improved with standard treatments. It also uses brain scans to predict who might respond best.

Budapest, Pest County

Hear when a new Treatment Resistant Depression (TRD) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.