Stopping hydroxychloroquine in older adults with stable lupus
Treatments studied
Part of Immune system & allergy, Skin clinical trials.
This study looks at whether it is safe for people aged 55 and older with long-standing, stable lupus to stop taking hydroxychloroquine (a medicine that helps control lupus) without their disease flaring up. If you have been taking this medicine for at least 7 years and your lupus has been quiet for a while, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 55 years old.
- You have had lupus for at least 7 years and your disease is currently not active (your doctor confirms you are in remission).
- You have been taking hydroxychloroquine (Plaquenil) by mouth at least 200 mg every day for at least 7 years.
- You are not on immunosuppressant drugs (like methotrexate or mycophenolate) or biologic medicines (like rituximab or belimumab).
- If you take prednisone, it must be at a dose of 5 mg or less per day, and you have not had a lupus flare in the past year.
- Your eyes were checked recently (within 6 months) for any signs of hydroxychloroquine-related damage.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether using mycophenolate mofetil plus tacrolimus can help people with lupus nephritis safely lower (taper) their prednisone to a low dose. It is designed for people whose kidney lupus has been well-controlled for at least 6 months.
This study tests a new medicine, TQH3906, in people with systemic lupus erythematosus (SLE) who have moderate to severe disease activity. It aims to see if TQH3906 can safely reduce lupus symptoms like joint pain, skin rash, or vasculitis.
This study tests a new drug called LBL-047 in healthy people and in people with mild to moderate lupus. It helps check if the drug is safe and how the body processes it. Participating may help find better treatments for lupus.
This trial tests an investigational drug called QLS4131 in people with active systemic lupus erythematosus (SLE) who are already on standard treatments. The goal is to see if adding QLS4131 can help control lupus activity better.
This study tests a new medicine called E6742 to help people with systemic lupus erythematosus (SLE), an autoimmune disease where the body attacks its own tissues. Researchers want to see if this drug can reduce lupus symptoms and disease activity.
This trial tests a single dose of an investigational drug called HC022 in healthy volunteers to see how safe it is and how the body handles it. If you are a healthy adult, you may be able to join and help researchers learn the first steps about this new medicine.
Hear when a new Systemic Lupus Erythematosus trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.