Treatment
Hydroxychloroquine clinical trials
We’re tracking 44 recruiting studies that include Hydroxychloroquine, each written for real people, not researchers, below.
Recruiting studies
- NCT05036226RecruitingPhase 1/Phase 2
COAST therapy for advanced prostate or other solid tumors
This early-phase trial tests the COAST therapy approach in people with advanced solid tumor cancers or advanced prostate cancer that has continued to grow despite standard treatments. The study aims to see how well the treatment works and whether it is safe enough to continue studying.
Charleston, South CarolinaAges 18 years+ - NCT05799378RecruitingPhase 3
Stopping hydroxychloroquine in older adults with stable lupus
This study looks at whether it is safe for people aged 55 and older with long-standing, stable lupus to stop taking hydroxychloroquine (a medicine that helps control lupus) without their disease flaring up. If you have been taking this medicine for at least 7 years and your lupus has been quiet for a while, you may be able to join.
Los Angeles, CaliforniaAges 55 years+ - NCT07750067RecruitingPhase 2
Combination therapy for advanced melanoma with NRAS mutation
This trial tests a combination of three drugs (tunlametinib, pucotenlimab, and hydroxychloroquine) for people with advanced melanoma that has a specific genetic change called NRAS. The goal is to see if this combination can shrink tumors or slow the cancer's growth.
Guangzhou, GuangdongAges 18 years+ - NCT06035887Recruiting
New eye test for hydroxychloroquine damage
This trial tests a new type of eye test (ERG) to detect early damage from hydroxychloroquine, a drug used for conditions like lupus and rheumatoid arthritis. If you take hydroxychloroquine or have never taken it, you might help find better ways to protect your vision.
London, LondonAges 18 years+ - NCT04911816RecruitingPhase 1/Phase 2
Pre-surgery chemo plus oral hydroxychloroquine for pancreatic cancer
This trial studies giving chemo and hydroxychloroquine before surgery for resectable pancreatic cancer. The goal is to shrink the tumor and improve the chances of successful removal.
Morgantown, West VirginiaAges 18 years+ - NCT06939582RecruitingPhase 1/Phase 2
Hydroxychloroquine for radiation mouth sores
This trial tests if hydroxychloroquine tablets can prevent or reduce mouth sores caused by radiation therapy for head and neck cancer. If you are about to start radiation for head and neck cancer and have not had radiation before, this study might help manage painful mouth sores.
Chengdu, SichuanAges 18–80 - NCT05953350RecruitingPhase 1/Phase 2
Hydroxychloroquine plus CDK4/6 medicine for advanced solid tumors
This trial tests whether adding hydroxychloroquine (a medicine that affects a cell recycling process called autophagy) can boost the anti-cancer effect of high-dose CDK4/6 inhibitor treatment in advanced solid tumors. It may help tumors respond better after prior CDK4/6 treatments have stopped working.
Guangzhou, GuangdongAges 18 years+ - NCT04523857RecruitingPhase 2
Abemaciclib and hydroxychloroquine after breast cancer relapse risk
This Phase 2 trial tests whether abemaciclib plus hydroxychloroquine can kill tiny “leftover” cancer cells in the bone marrow after standard breast cancer treatment. It may help lower the chance of cancer coming back by targeting minimal residual disease.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04532346RecruitingEarly Phase 1
Hydroxychloroquine for genetic lung disease in children
This early-phase trial studies whether hydroxychloroquine can help children with certain genetic causes of interstitial lung disease (lung scarring/inflammation). It is designed for kids who are currently stable and have not recently taken hydroxychloroquine.
Shanghai, Shanghai MunicipalityAges 1 month–18 years - NCT05113004RecruitingPhase 2
Testing new outcomes in primary Sjögren’s syndrome
This Phase 2 study tests how to measure changes in primary Sjögren’s syndrome symptoms and body activity. It may help researchers confirm which outcomes best reflect improvement and how different patient types respond to treatment.
BrestAges 18 years+ - NCT05126147RecruitingPhase 4
Hydroxychloroquine for mild Graves’ eye swelling
This trial studies whether hydroxychloroquine can improve mild Graves’ orbitopathy (swelling and discomfort around the eyes). It’s meant for people with mild symptoms and who haven’t recently used certain eye or immune treatments.
HsinchuAges 18–75 - NCT05287321RecruitingPhase 3
Aspirin plus hydroxychloroquine to prevent preeclampsia in high-risk pregnancy
This trial tests whether adding aspirin and hydroxychloroquine can lower the risk of preeclampsia during pregnancy in people considered high-risk. If you qualify, you may be assigned to take the study medicines to help protect you and the baby.
SeoulAges 19–50 - NCT05733000RecruitingPhase 2
CPI-613 plus hydroxychloroquine with chemo for advanced solid tumors
This trial tests a drug called CPI-613 (devimistat) combined with hydroxychloroquine along with either 5-fluorouracil or gemcitabine chemo. It’s for people with advanced cancers that have stopped responding to standard treatments, aiming to shrink tumors and slow cancer growth.
Chicago, IllinoisAges 18 years+ - NCT05841758RecruitingPhase 4
Hydroxychloroquine to reduce steroid use in sarcoidosis
This trial studies whether hydroxychloroquine can control extrapulmonary sarcoidosis (sarcoidosis outside the lungs) using less steroid treatment. It may help people who need systemic therapy for problems such as eyes, skin, bones, joints, nerves, ENT areas, or high calcium levels from sarcoidosis.
AvignonAges 18 years+ - NCT05961202RecruitingPhase 2/Phase 3
Hydroxychloroquine for inflammatory heart muscle weakness
This trial tests hydroxychloroquine to see if it improves symptoms and heart function in people with inflammatory cardiomyopathy (inflammation of the heart muscle). It’s mainly for adults with a specific type of past myocarditis and ongoing heart failure despite standard treatments.
Wuhan, HubeiAges 18–80 - NCT06229340RecruitingPhase 2
Two drug combinations for advanced cancer with RAS mutations
This trial tests two different treatment combinations (leflunomide alone or with MEK inhibitor and hydroxychloroquine) in people with advanced cancer that has a RAS mutation and has not responded to at least two prior therapies.
Saint PetersburgAges 18–85 - NCT06319560Recruiting
Hydroxychloroquine for type 2 diabetes during pregnancy
This study tests if hydroxychloroquine, a medicine sometimes used for autoimmune conditions, can help control blood sugar in pregnant women with type 2 diabetes. It aims to improve pregnancy outcomes for both mother and baby.
Cheras, Kuala LumpurAges 20–45 - NCT06350630RecruitingPhase 2
Hydroxychloroquine for IgA nephropathy
This trial tests whether hydroxychloroquine can help slow kidney damage in people with IgA nephropathy. You may qualify if you have this kidney disease, are already on two standard medicines (RAAS inhibitors and SGLT2 inhibitors), and have ongoing protein in your urine.
Clermont-FerrandAges 18 years+ - NCT06512753Recruiting
Hydroxychloroquine vs. Methotrexate for Lichen Planopilaris
This trial compares two medications, hydroxychloroquine and methotrexate, to see which works better for treating lichen planopilaris (a scalp condition that causes hair loss). Patients can choose their treatment or be assigned based on their health needs.
Rotterdam, South HollandAges 18–80 - NCT02735707RecruitingPhase 3
Adaptive trial for severe pneumonia care in intensive care
This study tests ways to improve treatment for adults with severe pneumonia that lands them in the ICU, adjusting the plan as results come in. It may help your care team find better treatments for lung infection and breathing/heart support needs.
Jacksonville, FloridaAges 18 years+ - NCT02714634RecruitingPhase 4
Methotrexate or leflunomide plus added therapy for rheumatoid arthritis
This study compares two combination treatments for rheumatoid arthritis in people whose current methotrexate or leflunomide isn’t working well enough. It aims to see whether adding a targeted therapy works better than the standard add-on of sulfasalazine plus hydroxychloroquine.
StrasbourgAges 18 years+ - NCT06408298RecruitingEarly Phase 1
Hydroxychloroquine before prostate cancer surgery
This trial tests whether a drug called hydroxychloroquine (HCQ) can help before prostate cancer surgery. It is for people with localized prostate cancer who are planning to have their prostate removed.
Lebanon, New HampshireAges 18 years+ - NCT06479304Recruiting
Hydroxychloroquine plus prednisone for ANA-positive ITP
This study tests whether a combination of hydroxychloroquine (HCQ) and prednisone (a steroid) is safe and effective for treating immune thrombocytopenia (ITP) in people who have a positive ANA blood test. It may be an option for those with low platelets and bleeding risk.
Shanghai, Shanghai MunicipalityAges 15–99 - NCT06479317Recruiting
Combining hydroxychloroquine and dexamethasone for ITP with positive ANA
This trial tests if adding hydroxychloroquine (HCQ) to the steroid dexamethasone (DEX) works better than dexamethasone alone for adults with immune thrombocytopenia (ITP) who have a positive antinuclear antibody (ANA) blood test. The goal is to see if this combination can safely raise platelet counts and reduce bleeding risk.
Shanghai, Shanghai MunicipalityAges 15–75
What Hydroxychloroquine is being studied for
Conditions with recruiting Hydroxychloroquine studies.
Common questions
- Are there clinical trials studying Hydroxychloroquine?
- Yes. Clin2 currently lists 44 recruiting studies that include Hydroxychloroquine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Hydroxychloroquine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Hydroxychloroquine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Hydroxychloroquine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.