Testing glofitamab plus polatuzumab for high-risk diffuse lymphoma
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This Phase 2 study tests two medicines—glofitamab and polatuzumab—together with chemotherapy to treat newly diagnosed, high-risk diffuse large B-cell lymphoma (DLBCL) that has the CD20 marker. It aims to improve how well the lymphoma responds and how long responses last.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have newly diagnosed CD20-positive diffuse large B-cell lymphoma (DLBCL), not previously treated (except limited steroid use or up to one cycle of R-CHOP).
- Your lymphoma type fits specific categories of aggressive/related B-cell lymphomas, as judged by the study team.
- You can provide usable tumor tissue from before starting (archived within 90 days) or you must have a new biopsy during screening.
- Your scan shows at least one measurable lymphoma spot on PET/CT (FDG-avid) measuring more than 1.5 cm.
- Your overall health scores are within limits: age 18+, and you can still do daily activities at level 0–2 (ECOG). Your heart and blood counts also must meet thresholds (including heart pumping strength ≥50%).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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