Ketamine infusions for depression in ICU patients
Treatments studied
Part of Mental health clinical trials.
This Phase 2 study tests whether ketamine infusions can reduce symptoms of clinical depression in people who are being treated in the ICU. It may help if your depression is significant and you meet the ICU and safety requirements.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be at Mayo Clinic Florida ICU and stay there for at least the last 1 week
- Have a PHQ-9 depression score of 10 or higher
- Have certain ICU diagnoses (like heart attack, kidney failure, severe breathing failure, end-stage liver disease, or after certain transplants/surgeries)
- Be medically stable: oxygen at least 95%, blood pressure not too low (<90) or too high (>180), and heart/breathing rates within limits
- You must not have safety or medication issues, including ketamine/diphenhydramine allergy, pregnancy/breastfeeding (or unable to do pregnancy testing), brain pressure/bleeding or an intracranial growth, psychosis history, or use of certain meds/substances that affect the brain receptor system
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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