Pembrolizumab versus monitoring after triple-negative breast cancer response
Treatments studied
Part of Cancer, Women’s health & pregnancy clinical trials.
This trial checks whether giving pembrolizumab (an immunotherapy) after surgery helps people with triple-negative breast cancer reduce the chance of the cancer coming back, compared with close monitoring only. It’s for patients who had no remaining invasive cancer after neoadjuvant chemotherapy plus pembrolizumab.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 or older.
- Your breast cancer is triple-negative (ER and PR are 10% or less, and HER2 is negative).
- After neoadjuvant chemotherapy plus pembrolizumab and surgery, there is no remaining invasive cancer in the breast or lymph nodes (DCIS is allowed).
- You completed at least 6 cycles of chemotherapy with pembrolizumab, and finished all chemotherapy before surgery.
- You must be within 12 weeks of finishing surgery before enrolling, and you must have acceptable blood counts and organ lab results.
- You must not be pregnant or nursing (and if you could become pregnant, you need a recent negative pregnancy test).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests if continuing pembrolizumab after surgery can help prevent breast cancer from coming back in people with triple-negative breast cancer who still had some cancer after initial chemo and pembrolizumab before surgery.
This trial aims to see if patients who had a complete response to chemo before surgery can safely stop or reduce their targeted therapy afterward. It includes people with early-stage HER2-positive or triple-negative breast cancer who had no cancer cells left in the tissue removed at surgery (a pathological complete response).
This Phase 1 study tests pembrolizumab (an immune medicine) to see how it affects the tumor and its surroundings in triple-negative breast cancer. It’s mainly looking at safety and early signs of benefit, especially in a limited, early-stage breast tumor.
This trial studies whether adding pembrolizumab (an immunotherapy) to standard chemotherapy before surgery improves immune and clinical responses in people with early-stage triple-negative breast cancer. You may benefit by getting a potentially more effective treatment plan, while the study team closely monitors your response.
This Phase 2 trial studies whether adding propranolol to pembrolizumab can “re-sensitize” tumors and slow cancer in triple-negative breast cancer that no longer responds to checkpoint immunotherapy. It may help some people whose cancer has grown despite prior pembrolizumab and chemotherapy.
This trial studies whether adding pembrolizumab (an immunotherapy) to standard chemotherapy after surgery can improve outcomes for people with early-stage triple-negative breast cancer. The treatment you receive depends on the level of immune cells (TILs) found in your tumor.
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