Optimizing treatment for early HER2+ and triple-negative breast cancer
Treatments studied
Part of Cancer clinical trials.
This trial aims to see if patients who had a complete response to chemo before surgery can safely stop or reduce their targeted therapy afterward. It includes people with early-stage HER2-positive or triple-negative breast cancer who had no cancer cells left in the tissue removed at surgery (a pathological complete response).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had early-stage HER2-positive or triple-negative breast cancer (confirmed by biopsy).
- You finished chemotherapy before surgery (neoadjuvant therapy) and had a complete response with no remaining invasive cancer in your breast or lymph nodes.
- You are willing to stop the targeted therapy (trastuzumab/pertuzumab for HER2+ or pembrolizumab for triple-negative) that you would normally take after surgery.
- You have not already received more than 3 cycles of these post-surgery targeted therapies.
- You are age 18 or older and medically stable enough to participate (including adequate blood counts and organ function).
- You have a stored sample of your original diagnostic tumor tissue available for testing.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 3 trial tests whether a shorter course of chemotherapy plus immunotherapy can work as well as standard treatment for early-stage triple-negative breast cancer. It avoids anthracycline drugs and may help reduce exposure to those medicines if the shorter plan is effective and safe.
This Phase 2 study looks at how well early breast cancer shrinks with treatment and how that matches with what doctors find after surgery under the microscope. The goal is to learn better ways to predict and assess treatment success.
This trial tests a neoadjuvant (before surgery) treatment plan for people with early-stage HER2-positive breast cancer. The goal is to see if a personalized approach can improve outcomes.
This trial tests different combinations of targeted therapy and chemotherapy before surgery for HER2-positive breast cancer. It uses a special PET scan to see how well the treatment is working and to help choose the best treatment plan for each person.
This trial tests a combination of targeted drugs and chemotherapy before surgery for HER2-positive breast cancer. It aims to see if this approach can shrink or eliminate the tumor, making surgery more effective.
This trial tests a combination of two drugs, trastuzumab deruxtecan (SHR-A1811) and pertuzumab, given before surgery to shrink HER2-positive breast cancer. It is for women with stage II or III breast cancer who have not yet had treatment and are in good overall health.
Hear when a new Anatomic Stage I Breast Cancer AJCC v8 trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.